Correcting the actual reproduction number: a simple method to estimate R(0) from early epidemic growth data.

Correcting the actual reproduction number: a simple method to estimate R(0) from early epidemic growth data.
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DOI:
10.3390/ijerph7010291
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发表时间:
2010-01
影响因子:
--
通讯作者:
Nishiura H
Nishiura H
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Nishiura H

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基本传染数 R0 是传染病传播潜力的概括衡量标准,是根据早期流行病增长率估算的,但尚未开发出基于可能性的估算方法。本研究纠正了实际再生数的概念,提供了一个简单的框架来估计 R0,而不假设病例呈指数增长。该方法应用于欧洲国家的艾滋病毒流行,得到的R0值范围为3.60至3.74,与基于Euler-Lotka方程的结果一致。该方法还允许使用电子表格计算 R0 的预期值。
The basic reproduction number, R0, a summary measure of the transmission potential of an infectious disease, is estimated from early epidemic growth rate, but a likelihood-based method for the estimation has yet to be developed. The present study corrects the concept of the actual reproduction number, offering a simple framework for estimating R0 without assuming exponential growth of cases. The proposed method is applied to the HIV epidemic in European countries, yielding R0 values ranging from 3.60 to 3.74, consistent with those based on the Euler-Lotka equation. The method also permits calculating the expected value of R0 using a spreadsheet.
DOI: 10.1098/rsif.2009.0153
发表时间: 2010-02-06
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