Association between nonalcoholic liver disease and chronic kidney disease: an ultrasound analysis from NHANES 1988-1994.
Association between nonalcoholic liver disease and chronic kidney disease: an ultrasound analysis from NHANES 1988-1994.
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DOI：
10.1159/000343885
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发表时间：
2012
影响因子：
4.2
通讯作者：
Jalal DI
中科院分区：
文献类型：
--
作者：
Sirota JC;McFann K;Targher G;Chonchol M;Jalal DI
非酒精性脂肪性肝病（NAFLD）被认为是慢性肾病（CKD）的独立危险因素。我们假设NAFLD与CKD相关，并且NAFLD的严重程度与CKD的几率较高相关。对11,469名参加1988-1994年国家健康和营养调查的成年人进行了横断面分析。NAFLD的定义是在没有其他肝脏疾病的情况下超声检测脂肪变性。CKD定义为估计肾小球滤过率≤60 mL/min/1.73 m2或估计肾小球滤过率>60 mL/min/1.73 m2的受试者存在蛋白尿。队列中有2，891例（25.4%）患者患有CKD。CKD患者的NAFLD患病率高于非CKD患者（42.2% vs. 34.5%，p<0.0001）。在未校正的逻辑回归分析中，NAFLD与CKD相关（比值比1.47，95%置信区间1.29-1.67，p<0.0001）。对人口统计学和代谢综合征组分的调整减弱了这种关系（比值比1.04，95%置信区间0.88-1.23，p=0.64）。在未校正的分析中，超声显示的中度和重度NAFLD与CKD患病率的相关性越来越高，但在校正代谢综合征组分后则无相关性。在调整代谢综合征的特征后，超声诊断的NAFLD与美国成年人中普遍存在的CKD无关。需要积极的公共卫生努力来预防和治疗代谢综合征。
Non-alcoholic fatty liver disease (NAFLD) has been proposed to contribute to chronic kidney disease (CKD) independently of traditional cardiometabolic risk factors. We hypothesized that NAFLD is associated with CKD and that greater severity of NAFLD is associated with higher odds of CKD. A cross-sectional analysis of 11,469 adults who participated in the National Health and Nutrition Examination Survey 1988–1994. NAFLD was defined by ultrasonographic detection of steatosis in the absence of other liver diseases. CKD was defined as an estimated glomerular filtration rate of ≤60 mL/min/1.73 m2 or the presence of albuminuria in subjects with an estimated glomerular filtration rate of >60 mL/min/1.73 m2. 2,891 (25.4%) patients in the cohort had CKD. The prevalence of NAFLD was higher in individuals with CKD compared to those without CKD (42.2% vs. 34.5%, p<0.0001). NAFLD was associated with CKD in unadjusted logistic regression analysis (odds ratio 1.47, 95% confidence interval 1.29–1.67, p<0.0001). Adjustment for demographics and components of metabolic syndrome attenuated this relationship (odds ratio 1.04, 95% confidence interval 0.88–1.23, p=0.64). Moderate and severe NAFLD on ultrasound were increasingly associated with prevalent CKD in unadjusted analysis but not after adjustment for metabolic syndrome components. After adjusting for features of metabolic syndrome, ultrasound-diagnosed NAFLD is not associated with prevalent CKD among US adults. Aggressive public health efforts are needed to prevent and treat metabolic syndrome.
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影响因子：
8.2
作者：
Targher, G.;Marra, F.;Marchesini, G.
通讯作者：
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影响因子：
16.2
作者：
Targher, Giovanni;Bertolini, Lorenzo;Arcaro, Guido
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影响因子：
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作者：
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影响因子：
1.6
作者：
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通讯作者：
Stenvinkel, Peter
DOI：
10.2215/cjn.05050610
发表时间：
2010-12-01
影响因子：
9.8
作者：
Targher, Giovanni;Bertolini, Lorenzo;Chonchol, Michel
通讯作者：
Chonchol, Michel