Susceptibility tensor imaging (STI) of the brain.
Susceptibility tensor imaging (STI) of the brain.
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DOI：
10.1002/nbm.3540
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发表时间：
2017-04
影响因子：
2.9
通讯作者：
Li, Xu
中科院分区：
文献类型：
--
作者：
Li, Wei;Liu, Chunlei;Duong, Timothy Q.;van Zijl, Peter C. M.;Li, Xu
关键词：
磁化率张量成像(STI)是最近发展起来的一种磁共振成像技术，它可以根据生物组织相对于主磁场方向的梯度回波信号相位的依赖关系来定量确定与方位无关的磁化率参数。通过将每个体素的磁化率建模为对称的秩2张量，可以确定单个磁化率张量元素以及在传统的基于标量的定量磁化率映射(QSM)消除这种相关性之后仍然显示方向相关性的脑组织的平均磁化率(MMS)和磁化率各向异性(MSA)。与扩散张量成像(DTI)类似，STI可以使用磁化率张量的主特征向量来绘制脑白质纤维方向图和重建3D白质路径。与弥散各向异性相反，脑白质磁化率各向异性的主要决定因素是髓鞘。脑白质磁化率各向异性的另一个独特特征是它对基于Gd的造影剂的敏感性。从机制上讲，MRI观察到的磁化率各向异性主要归因于髓鞘中高度有序的脂分子。STI在多个尺度上一致地解释了位相和磁化率对取向的依赖关系。本文回顾了导致STI发展的关键实验结果和物理理论，它的实际实施，以及它在脑研究中的应用。
Susceptibility tensor imaging (STI) is a recently developed MRI technique that allows quantitative determination of orientation-independent magnetic susceptibility parameters from the dependence of gradient echo signal phase on the orientation of biological tissues with respect to the main magnetic field. By modeling the magnetic susceptibility of each voxel as a symmetric rank-2 tensor, individual magnetic susceptibility tensor elements as well as the mean magnetic susceptibility (MMS) and magnetic susceptibility anisotropy (MSA) can be determined for brain tissues that would still show orientation dependence after conventional scalar-based quantitative susceptibility mapping (QSM) to remove such dependence. Similar to diffusion tensor imaging (DTI), STI allows mapping of brain white matter fiber orientations and reconstruction of 3D white matter pathways using the principal eigenvectors of the susceptibility tensor. In contrast to diffusion anisotropy, the main determinant factor of susceptibility anisotropy in brain white matter is myelin. Another unique feature of susceptibility anisotropy of white matter is its sensitivity to gadolinium-based contrast agents. Mechanistically, MRI-observed susceptibility anisotropy is mainly attributed to the highly ordered lipid molecules in myelin sheath. STI provides a consistent interpretation of the dependence of phase and susceptibility on orientation at multiple scales. This article reviews the key experimental findings and physical theories that led to the development of STI, its practical implementations, and its applications for brain research.
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DOI：
10.1002/mds.26417
发表时间：
2016-03
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Du G;Liu T;Lewis MM;Kong L;Wang Y;Connor J;Mailman RB;Huang X
通讯作者：
Huang X
影响因子：
5.7
作者：
Fan AP;Evans KC;Stout JN;Rosen BR;Adalsteinsson E
通讯作者：
Adalsteinsson E
影响因子：
3.7
作者：
Acosta-Cabronero J;Williams GB;Cardenas-Blanco A;Arnold RJ;Lupson V;Nestor PJ
通讯作者：
Nestor PJ
DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
11
作者：
Dominguez, Juan F. D.;Ng, Amanda C. L.;Georgiou-Karistianis, Nellie
通讯作者：
Georgiou-Karistianis, Nellie