Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia.
Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia.
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DOI：
10.1016/j.neuroimage.2014.09.068
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发表时间：
2015-01-01
期刊：
影响因子：
5.7
通讯作者：
Adalsteinsson E
中科院分区：
文献类型：
--
作者：
Fan AP;Evans KC;Stout JN;Rosen BR;Adalsteinsson E
对于局部脑氧合的非侵入性成像以管理中风、肿瘤和神经退行性疾病存在未满足的医疗需求。磁共振磁化率氧合成像是一种很有前途的新技术，可以测量大脑静脉血管沿着的局部静脉氧提取分数（OEF）。然而，这种方法尚未在不同氧合水平下进行体内测试。本研究的主要目的是测试是否氧合敏感性成像可以检测OEF的变化引起的高碳酸血症，通过二氧化碳吸入，在选定的先验脑区。用32通道头部线圈在3特斯拉下扫描10名健康受试者。连续监测呼气末CO2（ETCO 2），调整吸入气体以达到正常碳酸血症（41 ± 3 mmHg）和高碳酸血症（50 ± 4 mmHg）的稳态条件。在正常碳酸血症和高碳酸血症时分别采集梯度回波相位图像和伪连续动脉自旋标记（pcASL）图像，以测量局部OEF和CBF。通过假设在两种气体状态下恒定的脑耗氧量，计算区域CBF值以预测每个脑区域中OEF的局部变化。高碳酸血症导致直窦OEF相对降低-42.3%，大脑内静脉OEF相对降低-39.9%，引流枕叶、顶叶和额叶皮质区的软脑膜血管OEF相对降低约-50%。在志愿者中，OEF的区域变化与ETCO 2的变化相关。局部OEF的降低（通过相位图像）与来自CBF数据（通过pcASL图像）的OEF预测降低显著相关（P < 0.05）。这些研究结果表明，磁敏感成像是一种有前途的技术OEF测量，并可能作为一个临床生物标志物的大脑条件异常区域氧合。
There is an unmet medical need for noninvasive imaging of regional brain oxygenation to manage stroke, tumor, and neurodegenerative diseases. Oxygenation imaging from magnetic susceptibility in MRI is a promising new technique to measure local venous oxygen extraction fraction (OEF) along the cerebral venous vasculature. However, this approach has not been tested in vivo at different levels of oxygenation. The primary goal of this study was to test whether susceptibility imaging of oxygenation can detect OEF changes induced by hypercapnia, via CO2 inhalation, within selected a priori brain regions. Ten healthy subjects were scanned at 3 tesla with a 32-channel head coil. The end-tidal CO2 (ETCO2) was monitored continuously and inspired gases were adjusted to achieve steady-state conditions of eucapnia (41 ± 3 mmHg) and hypercapnia (50 ± 4 mmHg). Gradient echo phase images and pseudo-continuous arterial spin labeling (pcASL) images were acquired to measure regional OEF and CBF respectively during eucapnia and hypercapnia. By assuming constant cerebral oxygen consumption throughout both gas states, regional CBF values were computed to predict the local change in OEF in each brain region. Hypercapnia induced a relative decrease in OEF of -42.3% in the straight sinus, -39.9% in the internal cerebral veins, and approximately -50% in pial vessels draining each of the occipital, parietal, and frontal cortical areas. Across volunteers, regional changes in OEF correlated with changes in ETCO2. The reductions in regional OEF (via phase images) were significantly correlated (P < 0.05) with predicted reductions in OEF derived from CBF data (via pcASL images). These findings suggest that susceptibility imaging is a promising technique for OEF measurements, and may serve as a clinical biomarker for brain conditions with aberrant regional oxygenation.
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