In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease.
In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease.
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DOI：
10.1371/journal.pone.0081093
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Nestor PJ
中科院分区：
文献类型：
--
作者：
Acosta-Cabronero J;Williams GB;Cardenas-Blanco A;Arnold RJ;Lupson V;Nestor PJ
本研究探讨了静磁特性的阿尔茨海默氏症的大脑使用最近提出的，磁共振成像，后处理的对比机制。定量磁化率映射（QSM）有可能通过重建磁场扰动的磁化率源来监测体内铁水平。然而，对于在单个头部方向获得的相位数据，该技术依赖于几个理论近似，并且需要快速发展的正则化策略。在这种情况下，本研究描述了一个完整的方法框架的磁化率测量与审查其理论基础。阿尔茨海默病受试者和匹配的对照之间的区域和全脑横截面比较表明，可能有显着的磁敏感性差异脑深部核-特别是壳核-以及后部灰质和白色物质区域。所描述的方法和结果表明，QSM方法是准备进行大规模的临床研究。
This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies. In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations. The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei – particularly the putamen – as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies.
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影响因子：
4.8
作者：
Bianciardi, Marta;van Gelderen, Peter;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
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作者：
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