Mucus, commensals, and the immune system.
Mucus, commensals, and the immune system.
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DOI：
10.1080/19490976.2022.2041342
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Maynard CL
中科院分区：
文献类型：
--
作者：
Zhao Q;Maynard CL
大肠中的免疫系统与共生微生物和相对罕见的肠道病原体分开，被一层不同的上皮细胞覆盖着致密和粘附的内黏液层和松散的外黏液层。微生物，统称为黏液相关（MA）微生物群，物理上居住在这个黏液屏障中，导致动态和不间断的对话，以维持空间隔离和免疫耐受。最近的主要发现揭示了健康和疾病中免疫系统和黏液相关细菌之间串扰的新特征，以及指示宿主对这些生物反应的疾病相关外周免疫特征。在这篇简短的综述中，我们将这些新的观察结果整合到我们对结肠粘膜边界宿主-微生物群相互作用的总体理解中，并推测这一新兴知识对我们理解慢性肠道炎症的预防、发展和进展的重要性。
The immune system in the large intestine is separated from commensal microbes and comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with a compact and adherent inner mucus layer and a looser outer mucus layer. Microorganisms, collectively referred to as the mucus-associated (MA) microbiota, physically inhabit this mucus barrier, resulting in a dynamic and incessant dialog to maintain both spatial segregation and immune tolerance. Recent major findings reveal novel features of the crosstalk between the immune system and mucus-associated bacteria in health and disease, as well as disease-related peripheral immune signatures indicative of host responses to these organisms. In this brief review, we integrate these novel observations into our overall understanding of host-microbiota mutualism at the colonic mucosal border and speculate on the significance of this emerging knowledge for our understanding of the prevention, development, and progression of chronic intestinal inflammation.
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影响因子：
100.3
作者：
Chen, Kang;Magri, Giuliana;Grasset, Emilie K.;Cerutti, Andrea
通讯作者：
Cerutti, Andrea
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
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Gewirtz AT
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32.4
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Bendelac A
影响因子：
29.4
作者：
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通讯作者：
Elson CO
影响因子：
14.2
作者：
Christmann, Benjamin S.;Abrahamsson, Thomas R.;Elson, Charles O.
通讯作者：
Elson, Charles O.