Erythropoietin titers in anemic, nonuremic patients.

Erythropoietin titers in anemic, nonuremic patients.
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贫血、非尿毒症患者的促红细胞生成素滴度。

DOI:
10.5555/uri:pii:0022214387901156
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发表时间:
1987
期刊:
The Journal of laboratory and clinical medicine
影响因子:
--
通讯作者:
J. Caro
J. Caro
中科院分区:
--
文献类型:
--
作者:
A. Erslev;J. Wilson;J. Caro

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在33名正常志愿者和61名未合并肾脏或慢性疾病的贫血患者中,用生物测定法测定的与红细胞比容百分比相关的促红细胞生成素滴度与20名正常患者和28名类似贫血患者用放射免疫测定法测定的滴度重叠。用放射免疫法测定34例类风湿关节炎患者、25例镰状细胞性贫血患者(58个单独的样本)和28例血液学恶性肿瘤引起的红细胞发育不全患者的促红细胞生成素滴度,并与对照组的无并发症贫血患者进行比较,发现与该组的滴度无显著差异。12例再生障碍性贫血患者生物测定的促红细胞生成素滴度也在对照组的范围内。因此,这些贫血的促红细胞生成素滴度似乎主要由贫血程度决定,而不是由这些疾病对促红细胞生成素产生的任何特定影响决定。
Erythropoietin titers when related to the hematocrit percentage and measured by bioassay in 33 normal volunteers and in 61 patients with anemias not complicated by renal or chronic disease were found to overlap with titers measured by radioimmunoassay in 20 normals and 28 patients with similar anemias. Erythropoietin titers measured by radioimmunoassay in 34 patients with rheumatoid arthritis, 25 patients with sickle cell anemia (58 separate samples), and 28 patients with erythroid hypoplasia caused by hematologic malignancies were compared with those in the control group of patients with uncomplicated anemias and found not to differ significantly from titers in this group. Erythropoietin titers measured by bioassay in 12 patients with aplastic anemia also fell within the range of those in the control group. Consequently, erythropoietin titers in these anemias appear to be determined primarily by the degree of anemia and not by any specific effect of these illnesses on the production of erythropoietin.
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