Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer.
Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer.
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DOI：
10.1038/s41467-021-21093-8
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发表时间：
2021-02-05
影响因子：
16.6
通讯作者：
Jenner RA
中科院分区：
文献类型：
--
作者：
Undheim EAB;Jenner RA
毒液在动物体内进化了一百多次。毒液毒素被认为主要通过招募具有生理功能的内源性蛋白质来进化。在这里，我们报告的系统发育分析的毒液蛋白质组注释的毒腺转录组数据，辅助基因组分析，表明蜈蚣毒液招募了至少5个基因家族的细菌和真菌的捐助者，涉及至少8个水平的基因转移事件。这些结果建立了蜈蚣作为目前唯一已知的动物与毒液用于捕食和防御，包含来自水平基因转移的多个基因家族。这些结果也为水平基因转移在动物谱系毒液进化起源中的意义提供了第一个证据。其中三个细菌基因家族编码毒力因子，这表明水平基因转移可以通过细菌武器向动物毒液的延伸而为新奇的进化提供快速通道。动物毒液已经进化了很多次，主要是通过招募具有生理功能的内源性蛋白质。Undheim和詹纳发现，蜈蚣毒液从细菌和真菌供体中招募了至少5个基因家族，涉及至少8个水平基因转移事件。
Venoms have evolved over a hundred times in animals. Venom toxins are thought to evolve mostly by recruitment of endogenous proteins with physiological functions. Here we report phylogenetic analyses of venom proteome-annotated venom gland transcriptome data, assisted by genomic analyses, to show that centipede venoms have recruited at least five gene families from bacterial and fungal donors, involving at least eight horizontal gene transfer events. These results establish centipedes as currently the only known animals with venoms used in predation and defence that contain multiple gene families derived from horizontal gene transfer. The results also provide the first evidence for the implication of horizontal gene transfer in the evolutionary origin of venom in an animal lineage. Three of the bacterial gene families encode virulence factors, suggesting that horizontal gene transfer can provide a fast track channel for the evolution of novelty by the exaptation of bacterial weapons into animal venoms. Animal venoms have evolved many times primarily by recruitment of endogenous proteins with physiological functions. Undheim and Jenner find that centipede venoms have recruited at least five gene families from bacterial and fungal donors, involving at least eight horizontal gene transfer events.
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