Bacteria-autophagy interplay: a battle for survival.
Bacteria-autophagy interplay: a battle for survival.
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DOI：
10.1038/nrmicro3160
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Brumell JH
中科院分区：
文献类型：
--
作者：
Huang J;Brumell JH
自噬被细胞用来降解各种底物;这通过典型的非选择性自噬途径或通过选择性自噬来实现。这两种途径通过不同的关键步骤进行，并使用特定的分子机制。经典的自噬途径已经在哺乳动物细胞和模式生物（如酵母）中进行了详细研究。非经典自噬的分子机制，以及独立于一些关键自噬机制的替代途径，开始变得清晰。除了降解细胞蛋白质，自噬蛋白还参与许多其他功能，其中一些在细菌感染期间很重要。自噬作为一种抗菌机制发挥作用。已经阐明了几种细菌的诱导和识别机制。细菌可以通过自噬逃避杀死，有些甚至可以通过细菌效应蛋白和自噬组分之间的相互作用，利用自噬促进宿主细胞的感染。关于细菌-自噬相互作用的知识将为针对细菌感染的新药和治疗方法的设计提供信息。本文的在线版本（doi：10.1038/nrmicro 3160）包含补充材料，可供授权用户使用。自噬不仅降解宿主细胞的组分，而且还可以靶向细胞内细菌，从而有助于宿主防御。在这里，Huang和Brumell讨论了抗菌自噬的典型和选择性途径，以及细菌可以逃离它们的方式，有时甚至利用它们来促进感染。本文的在线版本（doi：10.1038/nrmicro 3160）包含补充材料，可供授权用户使用。自噬是一种细胞过程，将蛋白质、脂质和细胞器靶向溶酶体进行降解，但它也被证明可以对抗各种病原菌的感染。反过来，细菌已经开发出多种策略来通过干扰自噬信号或自噬机制来避免自噬，在某些情况下，它们甚至利用自噬来生长。在这篇综述中，我们讨论了经典和非经典的自噬途径以及我们目前对抗菌自噬的认识，重点是细菌因素和自噬成分之间的相互作用。本文的在线版本（doi：10.1038/nrmicro 3160）包含补充材料，可供授权用户使用。
Autophagy is used by the cell to degrade various substrates; this is achieved either through the canonical, non-selective autophagy pathway or through selective autophagy. Both pathways proceed via distinct key steps and use specific molecular mechanisms. The canonical autophagy pathway has been studied in detail in mammalian cells and in model organisms, such as yeast. The molecular mechanisms underlying non-canonical autophagy, in addition to alternative pathways that are independent of some of the key autophagy machinery, are beginning to become clear. Besides degradation of cellular proteins, autophagy proteins are also involved in many other functions, some of which are important during bacterial infections. Autophagy functions as an antibacterial mechanism. The induction and recognition mechanisms for several bacterial species have been elucidated. Bacteria can escape killing by autophagy and some can even use autophagy to promote infection of host cells, through the interaction between bacterial effector proteins and autophagy components. The knowledge about bacteria–autophagy interactions will inform the design of new drugs and treatments against bacterial infections. The online version of this article (doi:10.1038/nrmicro3160) contains supplementary material, which is available to authorized users. Autophagy not only degrades components of host cells but can also target intracellular bacteria and thus contribute to host defences. Here, Huang and Brumell discuss the canonical and selective pathways of antibacterial autophagy, as well as the ways in which bacteria can escape from them and sometimes even use them to promote infection. The online version of this article (doi:10.1038/nrmicro3160) contains supplementary material, which is available to authorized users. Autophagy is a cellular process that targets proteins, lipids and organelles to lysosomes for degradation, but it has also been shown to combat infection with various pathogenic bacteria. In turn, bacteria have developed diverse strategies to avoid autophagy by interfering with autophagy signalling or the autophagy machinery and, in some cases, they even exploit autophagy for their growth. In this Review, we discuss canonical and non-canonical autophagy pathways and our current knowledge of antibacterial autophagy, with a focus on the interplay between bacterial factors and autophagy components. The online version of this article (doi:10.1038/nrmicro3160) contains supplementary material, which is available to authorized users.
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DOI：
10.1126/science.1227026
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choy A;Dancourt J;Mugo B;O'Connor TJ;Isberg RR;Melia TJ;Roy CR
通讯作者：
Roy CR
影响因子：
6.7
作者：
Dortet L;Mostowy S;Samba-Louaka A;Gouin E;Nahori MA;Wiemer EA;Dussurget O;Cossart P
通讯作者：
Cossart P
影响因子：
9.2
作者：
Brumell, JH;Steele-Mortimer, O;Finlay, BB
通讯作者：
Finlay, BB
影响因子：
3.4
作者：
Amer, AO;Swanson, MS
通讯作者：
Swanson, MS
影响因子：
64.5
作者：
Dong, Na;Zhu, Yongqun;Shao, Feng
通讯作者：
Shao, Feng