The pathology of epstein-barr virus lymphoproliferations.
The pathology of epstein-barr virus lymphoproliferations.
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EB 病毒淋巴细胞增殖的病理学。
DOI：
10.1097/hs9.0000000000000227
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发表时间：
2019
期刊：
影响因子：
6.6
通讯作者：
Dojcinov SD
中科院分区：
文献类型：
--
作者：
Dojcinov SD
Epstein巴尔病毒（EBV）于20世纪60年代首次从地方性伯基特淋巴瘤（BL）中分离出来，现在被认为是迄今为止描述的最具致癌性的病毒。1，2大约95%的人口被感染。3急性感染后，病毒在宿主体内建立终身潜伏期。适应性免疫反应保持对潜伏在记忆B细胞库中的病毒的控制。4 EBV对淋巴细胞的转化主要由两个病毒基因LMP 1和EBNA 2驱动。然而，病毒基因表达的精确模式根据宿主免疫状态而变化，反映在3种主要的病毒潜伏模式中。潜伏期III与初始宿主的急性EBV感染和严重免疫缺陷相关，因为所有9种潜伏基因（核：EBNA 1，2，3A-C;膜：LMP 1，LMP 2A和LMP 2B）的不受限制的表达使感染细胞具有高度免疫原性。潜伏期II是一个中间程序，涉及除EBNA 2以外的大多数基因的表达。潜伏期I的特征在于EBNA 1的表达，EBNA 1对EBV基因组的维持和复制至关重要。
First isolated from endemic Burkitt’s lymphoma (BL) in the 1960s, Epstein Barr virus (EBV) is now recognized as the most oncogenic viruses ever described. 1, 2 Approximately 95% of the population are infected. 3 Following acute infection, the virus establishes lifelong latency in the host. Adaptive immune responses maintain control over the virus residing latently in the reservoir of memory B-cells. 4Transformation of lymphoid cells by EBV is primarily driven by two viral genes, LMP1 and EBNA2. However, the precise pattern of viral gene expression varies in accordance with the host immune state, reflected in 3 principal viral latency patterns. Latency III is associated with acute EBV infection in the naïve host and severe immunodeficiency, as unrestricted expression of all 9 latency genes (nuclear: EBNA1, 2, 3A–C; membrane: LMP1, LMP2A, and LMP2B) renders the infected cell highly immunogenic. Latency II is an intermediate program involving expression of most genes except EBNA2. Latency I is characterized by expression of the EBNA1, essential for maintenance and replication of the EBV genome.
器官移植受者中复发性 Epstein-Barr 病毒相关病变。
影响因子：
3.3
作者：
Wu,TT;Swerdlow,SH;Locker,J;Bahler,D;Randhawa,P;Yunis,EJ;Dickman,PS;Nalesnik,MA
通讯作者：
Nalesnik,MA
影响因子：
56.9
作者：
HENLE, W;DIEHL, V;HENLE, G
通讯作者：
HENLE, G
影响因子：
2.3
作者：
Linke-Serinsoez, Ebru;Fend, Falko;Quintanilla-Martinez, Leticia
通讯作者：
Quintanilla-Martinez, Leticia