Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity.
Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity.
复制标题
肠道微生物短链脂肪酸对免疫耐受和自身免疫的复杂调节作用。
DOI：
10.1038/s41423-023-00987-1
复制
发表时间：
2023-04
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
免疫耐受删除或抑制自身反应性淋巴细胞，并在T细胞和B细胞的发育、激活和效应阶段在多个水平上建立。这些机制是细胞内在编程的，对预防自身免疫性疾病至关重要。我们已经见证了另一种免疫耐受机制的存在，这种机制是由生活方式的选择所塑造的，比如饮食、微生物组和微生物代谢物。短链脂肪酸（SCFAs）是结肠内最丰富的微生物代谢物，主要由益生元（如膳食纤维）的微生物发酵产生。本文就SCFAs在自身免疫中的预防和免疫调节作用作一综述。本文讨论了膳食纤维、scfa和产生scfa的微生物对主要类型的自身免疫性疾病（包括I型糖尿病、多发性硬化症、类风湿性关节炎和狼疮）的组织和疾病特异性作用。此外，还讨论了它们在淋巴细胞发育、组织屏障功能、宿主代谢、免疫、自身抗体产生、炎症效应和调节淋巴细胞等方面的关键调节机制。讨论了SCFAs在不同类型和阶段自身免疫性疾病中的共同作用和差异作用。
Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at multiple levels during the development, activation and effector phases of T and B cells. These mechanisms are cell-intrinsically programmed and critical in preventing autoimmune diseases. We have witnessed the existence of another type of immune tolerance mechanism that is shaped by lifestyle choices, such as diet, microbiome and microbial metabolites. Short-chain fatty acids (SCFAs) are the most abundant microbial metabolites in the colonic lumen and are mainly produced by the microbial fermentation of prebiotics, such as dietary fiber. This review focuses on the preventive and immunomodulatory effects of SCFAs on autoimmunity. The tissue- and disease-specific effects of dietary fiber, SCFAs and SCFA-producing microbes on major types of autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and lupus, are discussed. Additionally, their key regulatory mechanisms for lymphocyte development, tissue barrier function, host metabolism, immunity, autoantibody production, and inflammatory effector and regulatory lymphocytes are discussed. The shared and differential effects of SCFAs on different types and stages of autoimmune diseases are discussed.
登录
查看更多内容
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
抗性淀粉摄入可通过调节肠道微生物群和促进丙酸产生来缓解小鼠胶原诱导的关节炎
影响因子：
12.8
作者：
Bai, Yunqiang;Li, Yanhong;Luo, Yubin
通讯作者：
Luo, Yubin
DOI：
10.1172/jci150985
发表时间：
2022-01-18
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Chen JW;Schickel JN;Tsakiris N;Sng J;Arbogast F;Bouis D;Parisi D;Gera R;Boeckers JM;Delmotte FR;Veselits M;Schuetz C;Jacobsen EM;Posovszky C;Schulz AS;Schwarz K;Clark MR;Menard L;Meffre E
通讯作者：
Meffre E
影响因子：
30.5
作者：
Aschenbrenner, Katharina;D'Cruz, Louise M.;Klein, Ludger
通讯作者：
Klein, Ludger
影响因子：
9.3
作者：
Bendotti, Giulia;Montefusco, Laura;Fiorina, Paolo
通讯作者：
Fiorina, Paolo