Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits
Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits
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杜泊羊和湖羊的全基因组重测序揭示与重要性状相关的选择特征
DOI：
10.1080/10495398.2022.2127409
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发表时间：
2022-10
影响因子：
3.7
通讯作者：
Wei Sun
中科院分区：
文献类型：
--
作者：
Xiaoyang Lv;Weihao Chen;Shanhe Wang;Xiukai Cao;Zehu Yuan;Tesfaye Getachew;Joram M. Mwacharo;Aynalem Haile;Wei Sun
Abstract Dorper and Hu sheep exhibit different characteristics in terms of reproduction, growth, and meat quality. Comparison of the genomes of two breeds help to reveal important genomic information. In this study, whole genome resequencing of 30 individuals (Dorper, DB and Hu sheep, HY) identified 15,108,125 single nucleotide polymorphisms (SNPs). Population differentiation (Fst) and cross population extended haplotype homozygosity (XP-EHH) were performed for selective signal analysis. In total, 106 and 515 overlapped genes were present in both the Fst results and XP-EHH results in HY vs DB and in DB vs HY, respectively. In HY vs DB, 106 genes were enriched in 12 GO terms and 83 KEGG pathways, such as ATP binding (GO:0005524) and PI3K-Akt signaling pathway (oas04151). In DB vs HY, 515 genes were enriched in 109 GO terms and 215 KEGG pathways, such as skeletal muscle cell differentiation (GO:0035914) and MAPK signaling pathway (oas04010). According to the annotation results, we identified a series of candidate genes associated with reproduction (UNC5C, BMPR1B, and GLIS1), meat quality (MECOM, MEF2C, and MYF6), and immunity (GMDS, GALK1, and ITGB4). Our investigation has uncovered genomic information for important traits in sheep and provided a basis for subsequent studies of related traits.
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影响因子：
9.3
作者：
Davegårdh C;Broholm C;Perfilyev A;Henriksen T;García-Calzón S;Peijs L;Hansen NS;Volkov P;Kjøbsted R;Wojtaszewski JF;Pedersen M;Pedersen BK;Ballak DB;Dinarello CA;Heinhuis B;Joosten LA;Nilsson E;Vaag A;Scheele C;Ling C
通讯作者：
Ling C
DOI：
10.1126/science.1252806
发表时间：
2014-06-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang Y;Xie M;Chen W;Talbot R;Maddox JF;Faraut T;Wu C;Muzny DM;Li Y;Zhang W;Stanton JA;Brauning R;Barris WC;Hourlier T;Aken BL;Searle SMJ;Adelson DL;Bian C;Cam GR;Chen Y;Cheng S;DeSilva U;Dixen K;Dong Y;Fan G;Franklin IR;Fu S;Guan R;Highland MA;Holder ME;Huang G;Ingham AB;Jhangiani SN;Kalra D;Kovar CL;Lee SL;Liu W;Liu X;Lu C;Lv T;Mathew T;McWilliam S;Menzies M;Pan S;Robelin D;Servin B;Townley D;Wang W;Wei B;White SN;Yang X;Ye C;Yue Y;Zeng P;Zhou Q;Hansen JB;Kristensen K;Gibbs RA;Flicek P;Warkup CC;Jones HE;Oddy VH;Nicholas FW;McEwan JC;Kijas J;Wang J;Worley KC;Archibald AL;Cockett N;Xu X;Wang W;Dalrymple BP
通讯作者：
Dalrymple BP
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.6
作者：
Li, Xin;Yang, Ji;Li, Meng-Hua
通讯作者：
Li, Meng-Hua
全基因组关联研究确定了西门塔尔肉牛内脏重量的位点和候选基因
影响因子：
4.6
作者：
An, Bingxing;Xia, Jiangwei;Gao, Huijiang
通讯作者：
Gao, Huijiang