Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial
Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial
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omega-3 脂肪酸对精神分裂症患者代谢综合征的影响：一项为期 12 周的随机安慰剂对照试验
DOI：
10.1007/s00213-018-5136-9
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发表时间：
2018-12
影响因子：
3.4
通讯作者：
Zhang Chen
中科院分区：
文献类型：
--
作者：
Xu Feikang;Fan Weixing;Wang Weiping;Tang Wei;Yang Fuyin;Zhang Yi;Cai Jun;Song Lisheng;Zhang Chen
精神分裂症患者由于其生活方式和抗精神病药物治疗，患代谢综合征（MetS）的风险增加。我们以前的研究表明，精神分裂症和代谢综合征患者肿瘤坏死因子-α（TNF-α）的表达和产生增加。Omega-3脂肪酸在抑制TNF-α方面有记录的作用;因此，在本发明中，我们假设，他们可能是在缓解炎症和改善代谢紊乱的精神分裂症和代谢综合征患者的价值。3脂肪酸对MetS在精神分裂症patients.MethodsWe招募了80例精神分裂症和MetS谁接受长期奥氮平单药治疗。结果精神分裂症合并代谢综合征患者TNF-α水平显著高于对照组（Z=-4.37，P < 0.01）。当患者完成这项研究时，omega-3脂肪酸治疗与甘油三酯（TG）水平降低之间存在显著相关性（F组×时间= 13.42; df = 1.66;P< 0.01）。沿着代谢改善，治疗12周后，omega-3脂肪酸降低了TNF-α水平（F组×时间= 6.71; df = 1，66;P= 0.012）。我们还发现TNF-α降低的程度与TG降低的程度显著相关（r= 0.38，P = 0.001）。结论我们的研究结果提供了提示性证据，表明omega-3脂肪酸对精神分裂症和MetS患者的TG代谢具有有益的影响，同时降低炎症水平。
RationaleIndividuals with schizophrenia are at increased risk of developing metabolic syndrome (MetS) due to their lifestyle and antipsychotic treatment. Our previous study showed that patients with both schizophrenia and MetS present an increased expression and production of tumor necrosis factor-alpha (TNF-alpha). Omega-3 fatty acids have a documented role in suppressing TNF-alpha; therefore, we hypothesized that they may be of value in relieving inflammation and improving metabolic disturbance in patients with both schizophrenia and MetS.ObjectivesThis study employed a randomized placebo-controlled trial to investigate the effects of omega-3 fatty acids on MetS in patients with schizophrenia.MethodsWe recruited 80 patients with both schizophrenia and MetS who received long-term olanzapine monotherapy. The patients were randomly assigned to the OMG-3 group (n= 40) or the placebo group (n= 40).ResultsPatients with both schizophrenia and MetS had significantly higher levels of TNF-alpha than the control subjects (Z= − 4.37,P< 0.01). There was a significant correlation between omega-3 fatty acid treatment and reduced triglyceride (TG) levels (Fgroup × time= 13.42; df = 1, 66;P< 0.01) when the patients completed this study. Along with metabolic improvement, omega-3 fatty acids decreased TNF-alpha levels after 12 weeks of treatment (Fgroup × time= 6.71; df = 1, 66;P= 0.012). We also found that the extent of TNF-alpha decrease was significantly correlated with that of TG decrease (r= 0.38,P= 0.001).ConclusionsOur findings provide suggestive evidence that omega-3 fatty acids have beneficial effects on TG metabolism in patients with both schizophrenia and MetS that parallel decreased inflammation levels.
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影响因子：
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作者：
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