Clinical Characteristics of Clonorchis sinensis-Associated Cholangiocarcinoma: A Large-Scale, Single-Center Study.
Clinical Characteristics of Clonorchis sinensis-Associated Cholangiocarcinoma: A Large-Scale, Single-Center Study.
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DOI：
10.3389/fmed.2021.675207
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发表时间：
2021
影响因子：
3.9
通讯作者：
Park JK
中科院分区：
文献类型：
--
作者：
Chang JI;Lee K;Kim D;Yang JI;Park JK;Choi K;Kang SH;Lee KH;Lee KT;Lee JK;Park SM;Park JK
背景：华支睾吸虫（CS）感染被认为是胆管癌（CCA）的第1组致癌物。关于CS相关CCA（CACC）的临床特征的研究很少。本研究的目的是调查CCA患者的临床特点，有或没有CS感染。方法：共367例诊断为CCA并接受CS感染诊断试验的患者入选。CS感染定义如下：至少一种阳性血清ELISA试验、皮肤试验、粪便显微镜检查或胆汁显微镜检查。结果：有95例（26%）患者发生CS感染。中位随访时间为14.9个月（范围：6.07-36.17）。CACC患者与非CACC患者相比存在以下显著差异：诊断年龄较低（中位数62岁vs. 65岁，p = 0.018），男性与女性比例较高（83.2% vs. 61.8%，p < 0.001），以及居住在CS流行区（46.3% vs. 25.4%，p = 0.014）。预后因素的单变量分析表明，肿瘤位置，根治性切除，肿瘤分期，实验室检查，包括CA 19-9，CEA和胆红素与总生存率显着相关，但CS感染不是。多因素分析显示，肿瘤部位、CEA、根治性切除和肿瘤分期是独立的预后因素。在64岁以下的患者中，CACC组的生存率低于非CACC组（p = 0.022）。结论：与非CACC相比，CACC具有以下显著特征：诊断年龄较低，男女比例较高，CS流行区的患病率较高，64岁以下患者的总生存率较差。
Background: Clonorchis sinensis (CS) infection is considered a group 1 carcinogen of cholangiocarcinoma (CCA). There were very few studies regarding clinical characteristics of CS-associated CCA (CACC). This study aimed to investigate clinical characteristics of patients with CCA with or without CS infection. Methods: A total of 367 patients diagnosed with CCA who underwent diagnostic tests for CS infection were enrolled. CS infection was defined as follows: at least one positive serum ELISA test, skin test, stool microscopy, or bile microscopy. Results: There were 95 (26%) patients with CS infections. The median follow-up duration was 14.9 months (range, 6.07–36.17). The following significant differences were noted among patients with CACC compared to non-CACC; diagnosis at younger age (median 62 years vs. 65 years, p = 0.018), higher male to female ratio (83.2 vs. 61.8%, p < 0.001), and residence in CS-endemic area (46.3 vs. 25.4%, p = 0.014). Univariate analysis of prognostic factors indicated that tumor location, curative resection, tumor stage, and laboratory tests including CA 19-9, CEA, and bilirubin were significantly associated with overall survival, but CS infection was not. In multivariate analysis, tumor location, CEA, curative resection and tumor stage were identified as independent prognostic factors. Among patients under age 64, CACC group had lower survival rate than non-CACC group (p = 0.022). Conclusions: CACC had the following significant characteristics compared to non-CACC; diagnosis at younger age, higher male to female ratio, higher prevalence in CS endemic areas and poorer overall survival in patients under age 64.
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影响因子：
2.6
作者：
Sastry, Amit V.;Abbadessa, Benjamin;Cooperman, Avram M.
通讯作者：
Cooperman, Avram M.
影响因子：
2.6
作者：
Kim, Hyo Jung;Kim, Jae Seon;Bak, Young-Tae
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Bak, Young-Tae
影响因子：
3
作者：
Vaeteewoottacharn, Kulthida;Seubwai, Wunchana;Wongkham, Sopit
通讯作者：
Wongkham, Sopit
DOI：
10.1111/j.1440-1746.2012.07207.x
发表时间：
2012-10-01
影响因子：
4.1
作者：
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通讯作者：
Gong, Jianping
影响因子：
9.8
作者：
Lee, Tae Y.;Lee, Sang S.;Suh, Dong J.
通讯作者：
Suh, Dong J.