The neuroendocrine physiology of female reproductive aging: An update.
The neuroendocrine physiology of female reproductive aging: An update.
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DOI：
10.1016/j.maturitas.2010.04.016
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发表时间：
2010-09
期刊：
影响因子：
4.9
通讯作者：
Dicken, Cary
中科院分区：
文献类型：
--
作者：
Neal-Perry, Genevieve;Nejat, Edward;Dicken, Cary
进入更年期是一个复杂的过程，影响生育能力，并增加老年妇女出现许多健康问题的风险，包括但不限于骨质疏松症、心脏病、糖尿病和认知功能障碍。营养的改善和医疗保健的增加延长了发达国家妇女的平均寿命，许多人将在绝经后状态下度过三分之一以上的生命。流行病学研究表明，推迟自然绝经可以延长寿命，并减缓许多与年龄有关的发病率的出现，这表明开发延迟绝经的治疗方法将大大提高妇女的生活质量。虽然绝经最终是由卵巢卵泡衰竭定义的，但人类和动物的几条科学证据表明，雌二醇反馈机制失调和下丘脑-垂体功能障碍有助于生殖衰老的发生和进展，与卵巢衰竭无关。本文简要介绍了我们目前对下丘脑-垂体轴在女性生殖衰老发生和过渡中的作用的认识。
The transition into menopause is a complex process that affects fertility and increases the risk for a number of health problems in aging women that include, but are not limited to osteoporosis, heart disease, diabetes mellitus and cognitive dysfunction. Improved nutrition and enhanced access to medical care have increased the average lifespan for women in developed countries, and many will spend more than one third of their life in a post-menopausal state. Epidemiological studies indicate that a delayed natural menopause confers longevity and decelerates the appearance of much age-related morbidity, suggesting that developing treatments to delay menopause would significantly improve quality of life for women. Although menopause is ultimately defined by ovarian follicular exhaustion, several lines of scientific evidence in humans and animals now suggest that dysregulation of estradiol feedback mechanisms and hypothalamic-pituitary dysfunction contributes to the onset and progression of reproductive senescence, independent of ovarian failure. This article provides a brief update on our current understanding of the role of the hypothalamic-pituitary axis in the onset of and transition into female reproductive senescence.
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影响因子：
2.9
作者：
Funabashi, T;Kleopoulos, SP;Mobbs, CV
通讯作者：
Mobbs, CV
影响因子：
2.9
作者：
Arias, P;Carbone, S;Moguilevsky, JA
通讯作者：
Moguilevsky, JA
影响因子：
7.2
作者：
Guthrie, JR;Dennerstein, L;Burger, HG
通讯作者：
Burger, HG
影响因子：
4.8
作者：
Hiney, Jill K.;Srivastava, Vinod K.;Dees, W. Les
通讯作者：
Dees, W. Les
DOI：
10.1159/000211394
发表时间：
1964-01-01
期刊：
GERONTOLOGIA
影响因子：
--
作者：
ASCHHEIM, P
通讯作者：
ASCHHEIM, P