Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs.
Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs.
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铋纳米颗粒和聚羟基丁酸酯涂层增强了可吸收下腔静脉滤器的射线不透性，用于猪的透视引导放置和纵向计算机断层扫描监测。
DOI：
10.1021/acsbiomaterials.1c01449
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发表时间：
2022-04-11
影响因子：
5.8
通讯作者：
Melancon, Marites P.
中科院分区：
文献类型：
--
作者：
Damasco, Jossana A.;Huang, Steven Y.;Perez, Joy Vanessa D.;Manongdo, John Andrew T.;Dixon, Katherine A.;Williams, Malea L.;Jacobsen, Megan C.;Barbosa, Roland;Canlas, Gino Martin;Chintalapani, Gouthami;Melancon, Adam D.;Layman, Rick R.;Fowlkes, Natalie W.;Whitley, Elizabeth M.;Melancon, Marites P.
用聚对二氧环己酮（PPDO）构建的下腔静脉滤器（IVCF）是金属滤器及其相关风险和并发症的有前途的替代品。结合高Z纳米颗粒（NP）可以提高PPDO IVCF的不透射线性，而不会对其安全性或性能产生不利影响。然而，这些研究增加的不透射线性不足以在透视引导PPDO IVCF展开期间实现滤器可视化。本研究的重点是使用铋纳米颗粒（BiNP）作为不透射线剂，为PPDO IVCF的透视引导展开和长期CT监测提供足够的信号强度。使用聚羟基丁酸酯（PHB）作为增加NP表面吸附的附加层，导致BiNP涂层增加2倍（BiNP-PPDO IVCF，3.8%，BiNP-PPDO+PHB IVCF，6.2%），从而在荧光透视引导的IVCF展开期间实现完全滤器可视化，1周后实现凝块展开。对照PPDO（断裂载荷，6.23±0.13 kg）、BiNP-PPDO（6.10±0.09 kg）和BiNP-PPDO+PHB（6.15±0.13 kg）IVCF的生物相容性、凝块捕获效率和机械强度在猪体内12周的监测期内没有显著差异。这些结果表明，BiNP-PPDO+PHB可增加新型可吸收IVCF的放射密度，而不影响器械强度。在常规射线照相成像下可视化器械是实现器械安全有效临床平移的关键。
Inferior vena cava filters (IVCFs) constructed with poly-p-dioxanone (PPDO) are promising alternatives to metallic filters and their associated risks and complications. Incorporating high-Z nanoparticles (NPs) improves PPDO IVCFs’ radiopacity without adversely affecting their safety or performance. However, increased radiopacity from these studies are insufficient for filter visualization during fluoroscopy-guided PPDO IVCF deployment. This study focuses on the use of bismuth nanoparticles (BiNP) as radiopacifiers to render sufficient signal intensity for the fluoroscopy-guided deployment and long-term CT monitoring of PPDO IVCFs. The use of polyhydroxybutyate (PHB) as an additional layer to increase the surface adsorption of NPs resulted in a 2-fold increase in BiNP coating (BiNP-PPDO IVCFs, 3.8%, BiNP-PPDO+PHB IVCFs, 6.2%), enabling complete filter visualization during fluoroscopy-guided IVCF deployment and, 1 week later, clot deployment. The biocompatibility, clot-trapping efficacy, and mechanical strength of the control PPDO (load-at-break, 6.23±0.13 kg), BiNP-PPDO (6.10±0.09 kg), and BiNP-PPDO+PHB (6.15±0.13 kg) IVCFs did not differ significantly over a 12-week monitoring period in pigs. These results indicate that BiNP-PPDO+PHB can increase the radiodensity of a novel absorbable IVCF without compromising device strength. Visualizing the device under conventional radiographic imaging is key to allow safe and effective clinical translation of the device.
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DOI：
10.1016/j.jvsv.2016.05.006
发表时间：
2016-10
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
4.2
作者：
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影响因子：
6.7
作者：
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