Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease.
Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease.
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DOI：
10.1002/mds.28360
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Bohnen NI
中科院分区：
文献类型：
--
作者：
van der Zee S;Müller MLTM;Kanel P;van Laar T;Bohnen NI
胆碱能系统在帕金森病（PD）的认知障碍中起着关键作用。以往的乙酰胆碱酯酶正电子发射断层扫描成像研究发现，记忆，注意力和执行功能相关的全球皮质胆碱能损失。囊泡乙酰胆碱转运体正电子发射断层扫描允许更准确的地形评估不仅皮质，而且皮质下胆碱能的变化。本研究的目的是探讨帕金森病患者认知功能与局部胆碱能神经支配之间的地形图关系。共86例非痴呆PD患者（平均± SD年龄67.8 ± 7.6岁，运动疾病持续时间5.8 ± 4.6年）和12例健康对照参与者（年龄67.8 ± 7.8岁）接受了胆碱能[18F]氟乙氧基苯并维索霉素正电子发射断层扫描成像。PD患者接受神经心理学评估。使用年龄匹配、性别匹配和教育水平匹配的对照组确定每个认知领域的z分数。特定领域的认知功能和胆碱能神经支配之间的相关性进行了检查，控制运动障碍和左旋多巴等效剂量。使用仅限于PD与正常衰老结合差异的掩码进行额外的相关性分析，以评估疾病特异性与正常衰老效应。基于体素的全脑分析表明，在认知领域的局部重叠地形，与记忆，注意力和执行功能领域的最强大的相关性（P < 0.01，多重比较校正）。共享的模式包括扣带皮层、小脑/盖和（视觉）丘脑。我们的研究结果证实并扩大了以往的观察胆碱能系统参与认知功能的PD。跨域的地形重叠可能反映了认知功能基础上的部分共享胆碱能功能，代表疾病特异性和衰老效应的组合。
The cholinergic system plays a key role in cognitive impairment in Parkinson’s disease (PD). Previous acetylcholinesterase positron emission tomography imaging studies found memory, attention, and executive function correlates of global cortical cholinergic losses. Vesicular acetylcholine transporter positron emission tomography allows for more accurate topographic assessment of not only cortical but also subcortical cholinergic changes. The objectiveof this study was to investigate the topographic relationship between cognitive functioning and regional cholinergic innervation in patients with PD. A total of 86 nondemented patients with PD (mean ± SD age 67.8 ± 7.6 years, motor disease duration 5.8 ± 4.6 years), and 12 healthy control participants (age 67.8 ± 7.8 years) underwent cholinergic [18F] Fluoroethoxybenzovesamicol positron emission tomography imaging. Patients with PD underwent neuropsychological assessment. The z scores for each cognitive domain were determined using an age-matched, gender-matched, and educational level–matched control group. Correlations between domain-specific cognitive functioning and cholinergic innervation were examined, controlling for motor impairments and levodopa equivalent dose. Additional correlational analyses were performed using a mask limited to PD versus normal aging binding differences to assess for disease-specific versus normal aging effects. Voxel-based whole-brain analysis demonstrated partial overlapping topography across cognitive domains, with most robust correlations in the domains of memory, attention, and executive functioning (P < 0.01, corrected for multiple comparisons). The shared pattern included the cingulate cortex, insula/operculum, and (visual) thalamus. Our results confirm and expand on previous observations of cholinergic system involvement in cognitive functioning in PD. The topographic overlap across domains may reflect a partially shared cholinergic functionality underlying cognitive functioning, representing a combination of disease-specific and aging effects.
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影响因子：
8.6
作者：
Goldman, Jennifer G.;Holden, Samantha;Ouyang, Bichun;Bernard, Bryan;Goetz, Christopher G.;Stebbins, Glenn T.
通讯作者：
Stebbins, Glenn T.
胆碱能和尾状核多巴胺能缺陷的频率在帕金森氏病的预测认知范围内以及相互作用效应的证据。
影响因子：
29
作者：
Bohnen NI;Albin RL;Müller ML;Petrou M;Kotagal V;Koeppe RA;Scott PJ;Frey KA
通讯作者：
Frey KA
影响因子：
4.3
作者：
Klein A;Tourville J
通讯作者：
Tourville J
影响因子：
9.9
作者：
Hilker, R;Thomas, AV;Heiss, WD
通讯作者：
Heiss, WD
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ