Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).
Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).
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孟加拉国铅暴露儿童的 Delta-氨基乙酰丙酸脱水酶 (ALAD) 多态性及其对尿氨基乙酰丙酸 (ALA) 的影响。
DOI：
10.1016/j.envres.2014.08.045
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发表时间：
2015
影响因子：
8.3
通讯作者：
C.
中科院分区：
文献类型：
--
作者：
Tasmin;S.;Furusawa;H.;Ahmad;SA.;Faruquee;MH.;Watanabe;C.
背景和目的铅一直被认为是一种有害的环境污染物。像孟加拉国这样的发展中国家的人仍然有更高的铅暴露风险。先前的研究表明，β-氨基酮丙酸脱水酶(ALAD)基因可以改变铅中毒和个体易感性。由于儿童更容易受到铅中毒的影响，本研究调查了在孟加拉国环境铅暴露的儿童中，ALAD基因是否会影响尿中的β-氨基乙酰丙酸(U-ALA)的排泄。共对222名儿童进行了研究。采血、尿测定ALAD基因分型、血铅和尿氨基乙酰丙酸(U-ALA)。血铅与血红蛋白呈显著正相关(p<；0.01)。ALAD 1和2的等位基因频率分别为0.83和0.17。男性ALAD-2/2-2携带者的平均U-ALA浓度低于ALAD-1携带者(P=0.001)。但对于女孩来说，U-ALA在不同的基因型之间没有显著差异(p=0.26)。在多元线性回归分析中，在相同暴露水平下按基因型比较，携带ALAD-2/2-2的男孩的U-ALA水平仍然低于携带ALAD-1的男孩。结论本研究提供了ALAD基因多态对孟加拉儿童的影响及其与U-ALA的关系。我们的结果表明，ALAD1-2/2-2基因可能对环境铅暴露的男童具有保护作用。
Background and objectiveLead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this study investigated whether the ALAD genotype influenced urinary excretion of delta-aminolevulinic acid (U-ALA) among children exposed to environmental lead in Bangladesh.MethodsSubjects were elementary schoolchildren from a semi-urban industrialized area in Bangladesh. A total of 222 children were studied. Blood and urine were collected to determine ALAD genotypes, blood lead levels and urinary aminolevulinic acid (U-ALA).ResultsThe mean BPb level was 9.7 µg/dl for the study children. BPb was significantly positively correlated with hemoglobin (p<0.01). In total, allele frequency for ALAD 1 and 2 was 0.83 and 0.17 respectively. The mean U-ALA concentration was lower in ALAD1-2/2-2 carriers than ALAD1-1 carriers for boys (p=0.001). But for girls, U-ALA did not differ significantly by genotype (p=0.26). When U-ALA was compared by genotype at the same exposure level in a multiple linear regression analysis, boys who were ALAD1-2/2-2 carriers still had a lower level of U-ALA compared to ALAD1-1carriers.ConclusionThis study provides information about the influence of ALAD polymorphism and its association with U-ALA in Bangladeshi children. Our results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of U-ALA for environmentally lead exposed boys.
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影响因子：
9.8
作者：
J. Wetmur;Angelina Kaya;M. Plewinska;Robert J. Desnickt
通讯作者：
J. Wetmur;Angelina Kaya;M. Plewinska;Robert J. Desnickt
影响因子：
10.4
作者：
通讯作者：
--
影响因子：
8.3
作者：
WETMUR, JG;LEHNERT, G;DESNICK, RJ
通讯作者：
DESNICK, RJ
δ-氨基乙酰丙酸脱水酶：人类新的遗传多态性
影响因子：
1.9
作者：
G. Battistuzzi;R. Petrucci;L. Silvagni;F. Urbani;S. Caiola
通讯作者：
S. Caiola
影响因子：
4.9
作者：
Strömberg, U;Lundh, T;Skerfving, S
通讯作者：
Skerfving, S