Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism.
Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism.
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DOI：
10.3390/jcm11051269
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发表时间：
2022-02-25
影响因子：
3.9
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nakamichi S;Nagata Y;Hayashida N;Maeda T
游离三碘甲状腺原氨酸（FT 3）与游离甲状腺素（FT 4）的比值（FT 3/FT 4）是甲状腺素脱碘的标志物，可反映甲状腺激素的活性。由于亚临床甲状腺功能减退症（SCH）和慢性肾脏病（CKD）之间的正相关性的报道，澄清FT 3/FT 4，SCH和CKD之间的关联可能是一个有效的工具，以制定预防CKD的策略。对1724名甲状腺激素正常的日本人进行了横断面研究。观察到SCH和CKD之间存在显著正相关;校正的比值比（OR）和95%置信区间（95% CI）为2.23（1.38，3.59）。尽管如此，发现FT 3/FT 4与CKD呈负相关，而与SCH呈正相关; FT 3/FT 4的1个标准差（SD）增量的校正OR和95% CI分别为0.51（0.35，0.74）（CKD）和2.40（1.34，4.29）（SCH）。FT 3/FT 4也与SCH（无CKD）呈正相关，但与CKD无关; SCH（无CKD）和SCH（伴CKD）的FT 3/FT 4的1 SD增量分别为3.44（1.72，6.91）和1.11（0.40，3.06）。虽然还需要进一步的研究，但目前的研究表明，即使在与CKD正相关的SCH中，外周甲状腺素脱碘活性较高也可能与CKD的缺乏有益相关。
The ratio of free triiodothyronine (FT3) to free thyroxine (FT4) (FT3/FT4), a maker of peripheral thyroxin deiodination, could indicate activity of thyroid hormone. Since positive association between subclinical hypothyroidism (SCH) and chronic kidney disease (CKD) was reported, clarifying the association among FT3/FT4, SCH, and CKD could be an efficient tool to make a strategy for preventing CKD. A cross-sectional study with 1724 Japanese with normal thyroid hormone was conducted. Significant positive association between SCH and CKD was observed; the adjusted odds ratio (OR) and 95% confidence interval (95% CI) was 2.23 (1.38, 3.59). Even though, FT3/FT4 was found to be inversely associated with CKD whereas positively associated with SCH; the adjusted ORs and 95% CIs for 1 standard deviation (SD) increment of FT3/FT4 were 0.51 (0.35, 0.74) for CKD and 2.40 (1.34, 4.29) for SCH, respectively. FT3/FT4 was also found to be positively associated with SCH without CKD but not those with CKD; 1 SD increment of FT3/FT4 were 3.44 (1.72, 6.91) for SCH without CKD and 1.11 (0.40, 3.06) for SCH with CKD, respectively. Although further investigation is necessary, present study indicates that higher activity of peripheral thyroxin deiodination might have beneficial association on absence of CKD even among SCH which is positively associated with CKD.
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影响因子：
3.7
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
通讯作者：
Hayashida N
影响因子：
8
作者：
Anderson, Josephine L. C.;Gruppen, Eke G.;Dullaart, Robin P. F.
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影响因子：
6.6
作者：
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通讯作者：
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影响因子：
2.8
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通讯作者：
McNab, Brian K.
影响因子：
5.6
作者：
Zemirli N;Morel E;Molino D
通讯作者：
Molino D