HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
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DOI：
10.1371/journal.pone.0253841
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Hayashida N
中科院分区：
文献类型：
--
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
在正常甲状腺人群中，抗甲状腺过氧化物酶抗体（TPO-Ab）与甲状腺囊肿呈负相关。TPO-Ab通过增强甲状腺炎症引起自身免疫性甲状腺炎。因此，至少在一定程度上，没有甲状腺囊肿可能提示潜在的甲状腺损伤。据报道，亚临床甲状腺功能减退患者的HbA1c高于正常健康对照者，因此HbA1c可能通过反映潜在甲状腺损伤的机制与甲状腺囊肿呈负相关。为了探讨甲状腺功能正常人群中HbA1c与甲状腺囊肿的关系，我们对1724名年龄在40-74岁、甲状腺功能正常范围内（即游离三碘甲状腺原氨酸（T3）和游离甲状腺素（T4）正常范围内）的日本人进行了横断面研究。在该研究人群中，564人被诊断为甲状腺囊肿。独立于甲状腺相关激素[促甲状腺激素（TSH），游离T3和游离T4]和已知的心血管危险因素，HbA1c被发现与甲状腺囊肿的存在显著负相关。即使该分析仅限于正常TSH范围内的参与者，这种关联仍然显著。HbA1c标准偏差（SD）增加1时，甲状腺囊肿的完全校正比值比（ORs）在所有受试者中为0.84(0.74,0.95)，在TSH正常范围内为0.80（0.70,0.92）。在甲状腺功能正常的参与者中，HbA1c与甲状腺囊肿的存在呈负相关。甲状腺囊肿的消失和HbA1c水平的升高提示甲状腺潜在的功能损害。
Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.
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影响因子：
3.7
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
通讯作者：
Hayashida N
影响因子：
3.1
作者：
Zhu, Ping;Liu, Xinliang;Mao, Xiaoming
通讯作者：
Mao, Xiaoming
影响因子：
2.1
作者：
Mohanty, Shruti;Amruthlal, W.;Rao, Pragna
通讯作者：
Rao, Pragna
影响因子：
0.6
作者：
Abdulateef, Darya S.;Mahwi, Taha O.
通讯作者：
Mahwi, Taha O.
DOI：
10.1111/j.1524-6175.2006.05180.x
发表时间：
2006-08-01
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
--
作者：
Prisant, L Michael;Gujral, Jaspal S;Mulloy, Anthony L
通讯作者：
Mulloy, Anthony L