Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta.
Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta.
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DOI：
10.1038/ncpcardio1444
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
El Aidi, Hamza;Mani, Venkatesh;Weinshelbaum, Karen B.;Aguiar, Silvia H.;Taniguchi, Hiroaki;Postley, John E.;Samber, Daniel D.;Cohen, Emil I.;Stern, Jessica;van der Geest, Rob J.;Reiber, Johan H. C.;Woodward, Mark;Fuster, Valentin;Gidding, Samuel S.;Fayad, Zahi A.
这项横断面研究的目的是测试颈动脉和胸降主动脉 (TOA) MRI 参数分析的重现性，评估斑块负荷的相关性以及与受试者年龄和性别的关联。 300 名具有心血管危险因素的受试者接受了颈动脉和 TOA 的黑血 MRI 扫描。手动测量平均壁面积、壁厚度、管腔面积、总血管面积和壁面积/总血管面积(WA/TVA)比率。分别对 187 名和 20 名随机选择的受试者进行了读者间和读者内的再现性测试。分析的观察者内重现性很高（组内相关系数 (ICC > 0.8)，TOA 的平均 WA/TVA 比率除外。同样，观察者间的重现性是可以接受的（平均壁面积、管腔面积和总血管面积的 ICC > 0.7）。主动脉和颈动脉的 MRI 参数随着年龄的增长而增加（p<0.001）。除了平均壁之外TOA 厚度和 WA/TVA 比值、MRI 参数在男性中显着高于女性。除了平均管壁厚度和 WA/TVA 比值之外，所有 MRI 测量结果均具有高度可重复性。颈动脉和主动脉之间的平均管壁面积与动脉粥样硬化的全身性质具有良好的相关性。与心血管疾病的临床表现类似，我们发现男性的大多数 MRI 参数（除了 WA/TVA 比值）的值均高于女性，并且随着年龄的增加。表明对斑块负荷的大多数 MRI 测量结果的分析是可重复的，并且颈动脉和主动脉之间的斑块负荷之间存在相关性，从而验证了疾病的全身分布。
This cross sectional study was conducted to test reproducibility of analysis of MRI parameters in carotids and thoracic descending aorta (TOA), evaluate the correlation of plaque burden and associations with subject age and gender. Three hundred subjects, with cardiovascular risk factors, underwent a black blood MRI of both carotids and TOA. Mean wall area, wall thickness, lumen area, total vessel area and wall area/total vessel area (WA/TVA) ratio were manually measured. Inter-reader and intra-reader-reproducibility was tested on 187 and 20 randomly chosen subjects respectively. The intra-observer-reproducibility for the analysis was high (Intraclass-Correlation-Coefficients (ICC’s >0.8), except mean WA/TVA ratio of TOA. Similarly, the inter-observer reproducibility was acceptable (ICC’s >0.7 for mean wall area, lumen area and total vessel area). MRI parameters in aorta and carotids increased with age for both sexes (p<0.001). Except for mean wall thickness of TOA and WA/TVA ratio, MRI parameters were significantly higher in males than in females. All MRI measurements except the mean wall thickness and WA/TVA ratio were highly reproducible. There was good correlation for mean wall area between carotids and aorta compatible with the systemic nature of atherosclerosis. Similar to clinical presentation of cardiovascular diseases we found greater values in most MRI parameters (except for WA/TVA ratio) in males than in females and with increasing age. These data suggest that analysis of most MRI measurements of plaque burden is reproducible and that there is correlation between plaque burden between carotids and aorta validating the systemic distribution of the disease.
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影响因子：
4.4
作者：
Itskovich, VV;Mani, V;Fayad, ZA
通讯作者：
Fayad, ZA
影响因子：
5
作者：
Li, AE;Kamel, I;Bluemke, DA
通讯作者：
Bluemke, DA
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
影响因子：
64.8
作者：
Sanz, Javier;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
DOI：
10.1016/s0735-1097(00)01119-0
发表时间：
2001-02-01
影响因子：
24
作者：
Haberl, R;Becker, A;Steinbeck, G
通讯作者：
Steinbeck, G