Overview of the Muscle Cytoskeleton.
Overview of the Muscle Cytoskeleton.
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DOI：
10.1002/cphy.c160033
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发表时间：
2017-06-18
影响因子：
5.8
通讯作者：
Gregorio CC
中科院分区：
文献类型：
--
作者：
Henderson CA;Gomez CG;Novak SM;Mi-Mi L;Gregorio CC
心脏和骨骼肌横纹肌是复杂设计的机器负责肌肉收缩。基本的收缩单位，肌节，和复杂的细胞骨架网络的协调是至关重要的收缩活动。肌节由精确组织的单个细丝系统组成，包括细（肌动蛋白）、粗（肌球蛋白）、肌联蛋白和星云蛋白。将肌节连接到其他细胞器（例如，线粒体和细胞核）并充当支架以维持细胞完整性的是中间丝。另一方面，肋节将肌节连接到细胞膜上。独特的结构，如心肌中的闰盘和骨骼肌中的肌腱连接，有助于同步和传递力。人们对构成这些细胞骨架组装体的许多蛋白质进行了深入的研究。然而，它们的功能细节以及它们如何相互连接才刚刚开始被阐明。大量的人类肌病是由肌肉蛋白质的突变引起的;因此，了解它们的基本功能提供了对肌肉疾病的机械理解。在这篇综述中，我们强调了横纹肌的组成部分，它们之间的相互作用，信号通路，功能和疾病的连接。
Cardiac and skeletal striated muscles are intricately designed machines responsible for muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the complex cytoskeletal networks are critical for contractile activity. The sarcomere is comprised of precisely organized individual filament systems that include thin (actin), thick (myosin), titin, and nebulin. Connecting the sarcomere to other organelles (e.g., mitochondria and nucleus) and serving as the scaffold to maintain cellular integrity are the intermediate filaments. The costamere, on the other hand, tethers the sarcomere to the cell membrane. Unique structures like the intercalated disc in cardiac muscle and the myotendinous junction in skeletal muscle help synchronize and transmit force. Intense investigation has been done on many of the proteins that make up these cytoskeletal assemblies. Yet the details of their function and how they interconnect have just started to be elucidated. A vast number of human myopathies are contributed to mutations in muscle proteins; thus understanding their basic function provides a mechanistic understanding of muscle disorders. In this review, we highlight the components of striated muscle with respect to their interactions, signaling pathways, functions, and connections to disease.
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影响因子：
--
作者：
Ackermann MA;Kontrogianni-Konstantopoulos A
通讯作者：
Kontrogianni-Konstantopoulos A
影响因子：
20.1
作者：
Alyonycheva, T;CohenGould, L;Mikawa, T
通讯作者：
Mikawa, T
影响因子：
4.4
作者：
Ackermann, Maegen A.;Kontrogianni-Konstantopoulos, Aikaterini
通讯作者：
Kontrogianni-Konstantopoulos, Aikaterini
影响因子：
16.2
作者：
ADAMS, ME;BUTLER, MH;FROEHNER, SC
通讯作者：
FROEHNER, SC
影响因子：
64.5
作者：
ARBER, S;HALDER, G;CARONI, P
通讯作者：
CARONI, P