Mechanisms of meiotic drive in symmetric and asymmetric meiosis.

Mechanisms of meiotic drive in symmetric and asymmetric meiosis.
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DOI:
10.1007/s00018-020-03735-0
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发表时间:
2021-04
期刊:
Cellular and molecular life sciences : CMLS
影响因子:
--
通讯作者:
Mueller JL
Mueller JL
中科院分区:
其他
文献类型:
--
作者:
Kruger AN;Mueller JL

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减数分裂驱动,染色体向下一代的非孟德尔传递,在单细胞和多细胞生物的不对称或对称减数分裂中发挥作用。在不对称减数分裂中,减数分裂驱动程序的作用是改变单个卵子中染色体的空间位置。在对称减数分裂中,减数分裂驱动程序导致有和没有驱动程序的配子之间的表型差异。在这里,我们讨论现有的模型减数分裂驱动器,突出最为人所知的基本机制和监管系统。我们专注于围绕这些例子的突出问题,并推测新的减数分裂驱动系统如何进化以及如何检测它们。
Meiotic drive, the non-Mendelian transmission of chromosomes to the next generation, functions in asymmetric or symmetric meiosis across unicellular and multicellular organisms. In asymmetric meiosis, meiotic drivers act to alter a chromosome’s spatial position in a single egg. In symmetric meiosis, meiotic drivers cause phenotypic differences between gametes with and without the driver. Here we discuss existing models of meiotic drive, highlighting the underlying mechanisms and regulation governing systems for which the most is known. We focus on outstanding questions surrounding these examples and speculate on how new meiotic drive systems evolve and how to detect them.
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