Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium.
Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium.
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DOI：
10.1371/journal.pone.0096774
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Botelho MC
中科院分区：
文献类型：
--
作者：
Santos J;Gouveia MJ;Vale N;Delgado Mde L;Gonçalves A;da Silva JM;Oliveira C;Xavier P;Gomes P;Santos LL;Lopes C;Barros A;Rinaldi G;Brindley PJ;da Costa JM;Sousa M;Botelho MC
血吸虫病是一种被忽视的热带疾病，在 76 个国家流行，影响着超过 2.4 亿人。根据最近的文献，血吸虫病对不孕症的影响可能被低估。埃及血吸虫提取物包含称为儿茶酚雌激素的雌激素样代谢物，可下调雌激素反应细胞中的雌激素受体α和β。此外，血吸虫衍生的儿茶酚雌激素会诱导基因毒性，导致雌激素-DNA 加合物。这些儿茶酚雌激素和儿茶酚-雌激素-DNA 加合物可以从埃及沙门氏菌感染者的血清中分离出来。本研究的目的是研究感染埃及沙门氏菌的女性不孕症及其与血吸虫源儿茶酚雌激素存在的关系。对安哥拉本戈省血吸虫病流行地区的女性居民进行了一项横断面研究。 93 名年龄从 2 岁（接受采访的父母）到 94 岁的妇女和女孩接受了采访，了解目前和以前的泌尿、泌尿生殖和妇科症状和主诉。收集参与者的尿液，用于基于鸡蛋的血吸虫感染寄生虫学评估，并用于液相色谱二极管阵列检测电子喷雾电离质谱（LC/UV-DAD/ESI-MSn）以研究尿液中的雌激素代谢物。在埃及血吸虫卵呈阳性的参与者的尿液中检测到可能源自血吸虫的新型雌激素样代谢物，但在埃及血吸虫卵阴性的尿液中未检测到。儿茶酚-雌激素/DNA加合物与血吸虫病显着相关（OR 3.35；95% CI 2.32–4.84；P≤0.001）。此外，这些代谢物的存在与不孕呈正相关（OR 4.33；95% CI 1.13–16.70；P≤0.05）。雌激素代谢物广泛存在于多种代谢途径中。鉴于儿茶酚-雌激素/DNA加合物与自我报告的不孕症之间存在统计学上显着的关联，我们提出雌激素-DNA加合物介导的途径可能参与埃及沙门氏菌诱导的卵巢激素失调。此外，此处描述的儿茶酚-雌激素/DNA 加合物代表了血吸虫病的潜在生物标志物。
Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts. These catechol estrogens and the catechol-estrogen-DNA adducts can be isolated from sera of people infected with S. haematobium. The aim of this study was to study infertility in females infected with S. haematobium and its association with the presence of schistosome-derived catechol-estrogens. A cross-sectional study was undertaken of female residents of a region in Bengo province, Angola, endemic for schistosomiasis haematobia. Ninety-three women and girls, aged from two (parents interviewed) to 94 years were interviewed on present and previous urinary, urogenital and gynecological symptoms and complaints. Urine was collected from the participants for egg-based parasitological assessment of schistosome infection, and for liquid chromatography diode array detection electron spray ionization mass spectrometry (LC/UV-DAD/ESI-MSn) to investigate estrogen metabolites in the urine. Novel estrogen-like metabolites, potentially of schistosome origin, were detected in the urine of participants who were positive for eggs of S. haematobium, but not detected in urines negative for S. haematobium eggs. The catechol-estrogens/ DNA adducts were significantly associated with schistosomiasis (OR 3.35; 95% CI 2.32–4.84; P≤0.001). In addition, presence of these metabolites was positively associated with infertility (OR 4.33; 95% CI 1.13–16.70; P≤0.05). Estrogen metabolites occur widely in diverse metabolic pathways. In view of the statistically significant association between catechol-estrogens/ DNA adducts and self-reported infertility, we propose that an estrogen-DNA adduct mediated pathway in S. haematobium-induced ovarian hormonal deregulation could be involved. In addition, the catechol-estrogens/ DNA adducts described here represent potential biomarkers for schistosomiasis haematobia.
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影响因子：
2.1
作者：
Botelho, M. C.;Crespo, M.;Correia da Costa, J. M.
通讯作者：
Correia da Costa, J. M.
DOI：
10.1111/j.1471-0528.1976.tb00751.x
发表时间：
1976-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
BULLOUGH, CHW
通讯作者：
BULLOUGH, CHW
影响因子：
3.8
作者：
Hotez PJ;Kamath A
通讯作者：
Kamath A
DOI：
10.1016/0020-7292(82)90072-8
发表时间：
1982-01-01
影响因子：
3.8
作者：
ELMAHGOUB, S
通讯作者：
ELMAHGOUB, S
DOI：
10.1073/pnas.94.20.10937
发表时间：
1997-09-30
影响因子：
11.1
作者：
Cavalieri, EL;Stack, DE;Rogan, EG
通讯作者：
Rogan, EG