Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK.
Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK.
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DOI：
10.1038/s41598-022-26433-2
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发表时间：
2022-12-24
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
社会经济地位（SEP）与较大的生物年龄相关，相对于实际年龄，通过DNA甲基化（正“年龄加速”，AA）测量。社会流动性被提议用来改善健康不平等。本研究旨在了解社会流动性与积极AA的关系。对角参考模型和普通最小二乘回归技术，探讨社会流动性和四个措施的年龄加速（第一代：“霍瓦特”，“汉纳姆”和第二代：“现象”，达尼丁PoAm）在n = 3140参与者的英国家庭纵向研究。生命早期的SEP异常与所检查的四种测量中的三种（Hannum、Phenoage和DunedinPoAm）的AA阳性相关，而第二代生物标志物与成年期的SEP相关（p < 0.01）。社会流动性与仅用Hannum测量的AA相关，因此与没有流动性相比，向上流动性与更大的年龄相关，而与来源和目的地SEP无关。与持续流动的群体相比，向下流动性与阳性表型年龄（1.06年[-0.03，2.14]）和DunedinPoAm评估的AA（0.96年[0.24，1.68]）相关。对于这两个指标，与持续处于不利地位的群体相比，向上流动与负AA相关（表型年龄，-0.65y [-1.30，-0.002];达尼丁PoAm，-0.96y [-1.47，-0.46]）。虽然我们找到了一些支持生命周期流行病学的三种模型，早期生活作为一个敏感时期，SEP在整个生命周期和社会流动性与DNA甲基化测量的年龄加速，我们的研究结果表明，不利的SEP在整个生命周期是最一致的积极AA。
Disadvantaged socio-economic position (SEP) is associated with greater biological age, relative to chronological age, measured by DNA methylation (positive ‘age acceleration’, AA). Social mobility has been proposed to ameliorate health inequalities. This study aimed to understand the association of social mobility with positive AA. Diagonal reference modelling and ordinary least square regression techniques were applied to explore social mobility and four measures of age acceleration (first-generation: ‘Horvath’, ‘Hannum’ and second-generation: ‘Phenoage’, DunedinPoAm) in n = 3140 participants of the UK Household Longitudinal Study. Disadvantaged SEP in early life is associated with positive AA for three (Hannum, Phenoage and DunedinPoAm) of the four measures examined while the second generation biomarkers are associated with SEP in adulthood (p < 0.01). Social mobility was associated with AA measured with Hannum only such that compared to no mobility, upward mobility was associated with greater age independently of origin and destination SEP. Compared to continuously advantaged groups, downward mobility was associated with positive Phenoage (1.06y [− 0.03, 2.14]) and DunedinPoAm assessed AA (0.96y [0.24, 1.68]). For these two measures, upward mobility was associated with negative AA (Phenoage, − 0.65y [− 1.30, − 0.002]; DunedinPoAm, − 0.96y [− 1.47, − 0.46]) compared to continually disadvantaged groups. While we find some support for three models of lifecourse epidemiology with early life as a sensitive period, SEP across the lifecourse and social mobility for age acceleration measured with DNA methylation, our findings suggest that disadvantaged SEP across the lifecourse is most consistently associated with positive AA.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
4.6
作者：
Castagne, Raphaele;Delpierre, Cyrille;Chadeau-Hyam, Marc
通讯作者：
Chadeau-Hyam, Marc
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S
影响因子：
6.3
作者：
George A;Hardy R;Castillo Fernandez J;Kelly Y;Maddock J
通讯作者：
Maddock J
影响因子：
5.5
作者：
Bateson, Patrick;Gluckman, Peter;Hanson, Mark
通讯作者：
Hanson, Mark