Life course socioeconomic position and DNA methylation age acceleration in mid-life.
Life course socioeconomic position and DNA methylation age acceleration in mid-life.
复制标题
DOI：
10.1136/jech-2020-215608
复制
发表时间：
2021-11
影响因子：
6.3
通讯作者：
Maddock J
中科院分区：
文献类型：
--
作者：
George A;Hardy R;Castillo Fernandez J;Kelly Y;Maddock J
老龄化生物标记物可以帮助我们更好地理解老龄化中公认的社会经济地位(SEP)差异是如何发生的。一组有希望的新的基于dNaM甲基化(DNaM)的老化生物标记物通过其年龄加速(AA)措施表明生物老化是慢于还是快于时间老化。很少有研究研究体感诱发电位与dNaM AA之间的关系。我们使用MRC全国健康与发展调查的数据，使用第一代(Horvath AA和Hannum AA)和第二代(PhenoAge AA和Grimage AA)dNaM AA标记，使用线性回归检验了儿童社会阶层、成人社会阶层、代际社会阶层变化、教育和成人家庭收入之间的性别调整关系。在第一代生物标志物中，几乎没有证据表明与Horvath AA有任何关联，但观察到童年社会阶层和收入与Hannum AA之间的关联。在第二代生物标记物中，儿童和成人SEP中较大的不利因素与较大的AA之间存在很强的相关性。例如，那些在童年时父亲属于非技能职业社会阶层的人比那些父亲来自专业社会阶层的人有3.6年的现像年龄AA(95% CI为1.8%至5.4%)。与受过高等教育的人相比，没有学历的人有更高的再生障碍率(4.1年)(95% CI3.1~5.0)。我们的发现强调了儿童时期暴露于社会劣势对生物衰老过程的重要性。第二代时钟似乎对整个生命过程中社会劣势的积累更加敏感。
Ageing biomarkers can help us better understand how well-established socioeconomic position (SEP) disparities in ageing occur. A promising new set of DNAm methylation (DNAm)-based ageing biomarkers indicate through their age acceleration (AA) measures if biological ageing is slower or faster than chronological ageing. Few studies have investigated the association between SEP and DNAm AA. We used linear regression to examine the sex-adjusted relationships between childhood social class, adult social class, intergenerational social class change, education and adult household earnings with first (Horvath AA and Hannum AA) and second generation (PhenoAge AA and GrimAge AA) DNAm AA markers using data from the MRC National Survey of Health and Development. In the first-generation biomarkers, there was little evidence of any associations with Horvath AA but associations of childhood social class and income with Hannum AA were observed. Strong associations were seen between greater disadvantage in childhood and adult SEP and greater AA in the second generation biomarkers. For example, those with fathers in an unskilled occupational social class in childhood had 3.6 years greater PhenoAge AA (95% CI 1.8 to 5.4) than those with fathers from a professional social class. Individuals without qualifications had higher AA compared with those with higher education (4.1 years greater GrimAge AA (95% CI 3.1 to 5.0)). Our findings highlight the importance of exposure to social disadvantage in childhood to the biological ageing process. The second generation clocks appear to be more sensitive to the accumulation of social disadvantage across the life course.
登录
查看更多内容
影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
3.5
作者：
Lawn RB;Anderson EL;Suderman M;Simpkin AJ;Gaunt TR;Teschendorff AE;Widschwendter M;Hardy R;Kuh D;Relton CL;Howe LD
通讯作者：
Howe LD
DOI：
10.1111/j.1749-6632.2011.06202.x
发表时间：
2012-01-01
期刊：
ADDICTION REVIEWS
影响因子：
--
作者：
Hiscock, Rosemary;Bauld, Linda;Munafo, Marcus
通讯作者：
Munafo, Marcus
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S