Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo.
Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo.
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DOI：
10.1111/j.1582-4934.2011.01412.x
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发表时间：
2012-06
影响因子：
5.3
通讯作者：
Pouliot M
中科院分区：
文献类型：
--
作者：
Dumas A;Lagarde S;Laflamme C;Pouliot M
抑瘤素M（Oncostatin M，OSM）是IL-6家族的一种多效性细胞因子，具有促炎和抗炎活性。我们研究了OSM对人类滑膜细胞基因激活谱的影响，滑膜细胞在关节炎症反应的进展中起着核心作用。在脂多糖和重组人粒细胞-巨噬细胞集落刺激因子刺激的滑膜细胞中，重组人OSM和人粒细胞分泌的天然OSM均降低IL-1β和CXCL 8的基因表达和分泌，但增加IL-6和CCL 2的基因表达和分泌。使用IL-6或白血病抑制因子未获得对滑膜细胞活化的这种影响。信号转导子和转录激活子-1似乎介导OSM对刺激的人滑膜成纤维细胞的影响。在小鼠背部气囊炎症模型中，OSM降低了衬里组织中促炎细胞因子IL-1β和TNF-α的表达及其在腔中的存在。这些结果总体上表明OSM的抗炎作用，引导炎症过程走向解决。
Oncostatin M (OSM) is a pleiotropic cytokine of the IL-6 family and displays both pro-inflammatory and anti-inflammatory activities. We studied the impact of OSM on the gene activation profile of human synovial cells, which play a central role in the progression of inflammatory responses in joints. In synovial cells stimulated with lipopolysaccharide and recombinant human granulocyte-macrophage colony-stimulating factor, recombinant human OSM and native OSM secreted by human granulocytes both reduced the gene expression and secretion of IL-1β and CXCL8, but increased that of IL-6 and CCL2. This impact on synovial cell activation was not obtained using IL-6 or leukaemia inhibitory factor. Signal transducer and activator of transcription-1 appeared to mediate the effects of OSM on stimulated human synovial fibroblasts. In the murine dorsal air pouch model of inflammation, OSM reduced the expression of the pro-inflammatory cytokines IL-1β and TNF-α in lining tissues, and their presence in the cavity. These results as a whole suggest an anti-inflammatory role for OSM, guiding inflammatory processes towards resolution.
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影响因子：
4
作者：
Cadieux, JS;Leclerc, P;Pouliot, M
通讯作者：
Pouliot, M
影响因子：
5.5
作者：
Goldring, SR
通讯作者：
Goldring, SR
影响因子：
27.4
作者：
Buckley, CD;Filer, A;Salmon, M
通讯作者：
Salmon, M
影响因子：
6.4
作者：
Dussault, AA;Pouliot, M
通讯作者：
Pouliot, M
影响因子：
7.3
作者：
EDWARDS, JCW;SEDGWICK, AD;WILLOUGHBY, DA
通讯作者：
WILLOUGHBY, DA