Simultaneous measurement of biochemical phenotypes and gene expression in single cells.
Simultaneous measurement of biochemical phenotypes and gene expression in single cells.
复制标题
同时测量单细胞中的生化表型和基因表达。
DOI:
10.1093/nar/gkaa240
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发表时间:
2020
影响因子:
14.9
通讯作者:
Hesselberth,JayR
中科院分区:
文献类型:
--
作者:
Richer,AmandaL;Riemondy,KentA;Hardie,Lakotah;Hesselberth,JayR
Methods to measure heterogeneity among cells are rapidly transforming our understanding of biology but are currently limited to molecular abundance measurements. We developed an approach to simultaneously measure biochemical activities and mRNA abundance in single cells to understand the heterogeneity of DNA repair activities across thousands of human lymphocytes, identifying known and novel cell-type-specific DNA repair phenotypes.
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影响因子:
--
作者:
Zenklusen, Daniel;Singer, Robert H.
通讯作者:
Singer, Robert H.
影响因子:
--
作者:
Park, Hye Yoon;Buxbaum, Adina R.;Singer, Robert H.
通讯作者:
Singer, Robert H.
影响因子:
16
作者:
Bertrand, E;Chartrand, P;Long, RM
通讯作者:
Long, RM
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
Taniguchi;Y.;Choi;P.J.;Li;G;Chen;H.;Hearn;J.;Babu;M.;Emili;A.;Xie;X.S.
通讯作者:
X.S.
DOI:
10.1073/pnas.212358999
发表时间:
2002-10-15
影响因子:
11.1
作者:
Adelman, K;La Porta, A;Wang, MD
通讯作者:
Wang, MD