Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.
Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.
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DOI：
10.1016/j.kint.2016.12.037
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发表时间：
2017-07
影响因子：
19.6
通讯作者：
Neuwelt EA
中科院分区：
文献类型：
--
作者：
Toth GB;Varallyay CG;Horvath A;Bashir MR;Choyke PL;Daldrup-Link HE;Dosa E;Finn JP;Gahramanov S;Harisinghani M;Macdougall I;Neuwelt A;Vasanawala SS;Ambady P;Barajas R;Cetas JS;Ciporen J;DeLoughery TJ;Doolittle ND;Fu R;Grinstead J;Guimaraes AR;Hamilton BE;Li X;McConnell HL;Muldoon LL;Nesbit G;Netto JP;Petterson D;Rooney WD;Schwartz D;Szidonya L;Neuwelt EA
对比增强磁共振成像（MRI）是一种常用的诊断工具。与标准钆造影剂相比，ferumoxytol（Feraheme，AMAG Pharmaceuticals，Waltham，MA）用作替代造影剂，对于肾功能受损的患者是可行的。静脉注射 (IV) 菲鲁莫托的其他有吸引力的成像特征包括延长的血池相和延迟的细胞内摄取。凭借其独特的药理学、代谢和成像特性，ferumoxytol 可能在未来中枢神经系统 (CNS)、CNS 以外的各种器官和心血管系统的 MR 成像中发挥至关重要的作用。临床前和临床研究已经证明了这种新型造影剂的总体安全性和有效性，并且很少发生过敏样反应。本综述的目的是描述 Ferumoxytol 的一般和器官特异性特性，以及与其在 MRI 中使用相关的优点和潜在缺陷。为了更全面地展示费鲁莫托在全身的应用，创建了成像图集并可在线作为补充材料。
Contrast-enhanced magnetic resonance imaging (MRI) is a commonly used diagnostic tool. Compared to the standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of intravenous (IV) ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacological, metabolic and imaging properties, ferumoxytol may play a crucial role in future MR imaging of the central nervous system (CNS), various organs outside the CNS, and the cardiovascular system. Preclinical and clinical studies have demonstrated the overall safety and effectiveness of this novel contrast agent with rarely occurring anaphylactoid reactions. The purpose of this review is to describe the general and organ specific properties of ferumoxytol, as well as the advantages and potential pitfalls associated with its use in MRI. In order to more fully demonstrate the applications of ferumoxytol throughout the body, an imaging atlas was created and is available as supplementary material online.
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影响因子：
7.5
作者：
Alam, Shirjel R.;Shah, Anoop S. V.;Semple, Scott I. K.
通讯作者：
Semple, Scott I. K.
DOI：
10.1158/1078-0432.ccr-10-3420
发表时间：
2011-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Daldrup-Link HE;Golovko D;Ruffell B;Denardo DG;Castaneda R;Ansari C;Rao J;Tikhomirov GA;Wendland MF;Corot C;Coussens LM
通讯作者：
Coussens LM
影响因子：
5.7
作者：
D'Arceuil, Helen;Coimbra, Alexandre;Triano, Pamela;Dougherty, Margaret;Mello, Julie;Moseley, Michael;Glover, Gary;Lansberg, Maarten;Blankenberg, Francis
通讯作者：
Blankenberg, Francis
影响因子：
3.3
作者：
Blockley, N. P.;Jiang, L.;Gowland, P. A.
通讯作者：
Gowland, P. A.
影响因子：
8.3
作者：
Dosa, Edit;Tuladhar, Suchita;Neuwelt, Edward A.
通讯作者：
Neuwelt, Edward A.