Carbapenemase-producing Enterobacteriaceae.
Carbapenemase-producing Enterobacteriaceae.
复制标题
DOI：
10.1055/s-0035-1544208
复制
发表时间：
2015-02
影响因子：
3.2
通讯作者：
Paterson DL
中科院分区：
文献类型：
--
作者：
Doi Y;Paterson DL
Carbapenemase-producing Enterobacteriaceae (CPE) were almost nonexistent up to the 1990s, but are today encountered routinely in hospitals and other healthcare facilities in many countries including the United States. KPC-producing Klebsiella pneumoniae was the first to emerge and spread globally and is endemic in the United States, Israel, Greece, and Italy. Recently, NDM-producing Enterobacteriaceae and OXA-48-producing K. pneumoniae appear to be disseminating from South Asia and Northern Africa, respectively. They are almost always resistant to all β-lactams including carbapenems and many other classes. Mortality from invasive CPE infections reaches up to 40%. To obtain the maximal benefit from the limited options available, dosing of antimicrobial agents should be optimized based on pharmacokinetic data, especially for colistin and carbapenems. In addition, multiple observational studies have associated combination antimicrobial therapy with lower mortality compared with monotherapy for these infections. The outcomes appear to be especially favorable when patients are treated with a carbapenem and a second agent such as colistin, tigecycline, and gentamicin, but the best approach is yet to be defined.
登录
查看更多内容
DOI：
10.1016/j.diagmicrobio.2014.06.010
发表时间：
2014-10
影响因子：
2.9
作者：
Ahn, Chulsoo;Syed, Alveena;Hu, Fupin;O'Hara, Jessica A.;Rivera, Jesabel I.;Doi, Yohei
通讯作者：
Doi, Yohei
影响因子：
4.9
作者：
Bulik, Catharine C.;Nicolau, David P.
通讯作者：
Nicolau, David P.
影响因子：
4.9
作者：
Daikos, George L.;Tsaousi, Sophia;Skoutelis, Athanasios
通讯作者：
Skoutelis, Athanasios
影响因子：
14.2
作者：
Capone, A.;Giannella, M.;Petrosillo, N.
通讯作者：
Petrosillo, N.
影响因子：
4.9
作者：
Castanheira, Mariana;Deshpande, Lalitagauri M.;Mendes, Rodrigo E.
通讯作者：
Mendes, Rodrigo E.