Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.
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DOI：
10.1016/j.diagmicrobio.2014.06.010
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发表时间：
2014-10
影响因子：
2.9
通讯作者：
Doi, Yohei
中科院分区：
文献类型：
--
作者：
Ahn, Chulsoo;Syed, Alveena;Hu, Fupin;O'Hara, Jessica A.;Rivera, Jesabel I.;Doi, Yohei
关于产KPC肠杆菌属的微生物学数据是稀缺的在本研究中，从2009年至2013年在宾夕法尼亚州西部的一家医院系统收集的44株厄他培南非敏感肠杆菌属分离株中鉴定出11株独特的产KPC肠杆菌属分离株。所有病例均与医疗保健相关，发生在医学复杂的患者中。虽然脉冲场凝胶电泳（PFGE）显示出不同的限制性模式的整体，多位点序列分型（MLST）确定的序列类型（ST）93和171从两家医院的阴沟肠杆菌分离株。碳青霉烯最低抑菌浓度水平差异很大。所有分离株仍对粘菌素、替加环素敏感，大多数对阿米卡星和多西环素敏感。一个blaKPC携带IncN质粒，赋予甲氧苄啶-磺胺甲恶唑耐药，确定在三个菌株。blaKPC在肠杆菌属中的传播。似乎是由于质粒介导和克隆过程的组合。
Microbiological data regarding KPC-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-non-susceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis (PFGE) showed diverse restriction patterns overall, multilocus sequence typing (MLST) identified Enterobacter cloacae isolates with sequence types (STs) 93 and 171 from two hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin, tigecycline, and the majority to amikacin and doxycycline. A blaKPC-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in three of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.
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影响因子：
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DOI：
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DOI：
10.1016/s1473-3099(13)70190-7
发表时间：
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期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
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