Learning from nature - novel synthetic biology approaches for biomaterial design.
Learning from nature - novel synthetic biology approaches for biomaterial design.
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DOI：
10.1016/j.actbio.2014.01.019
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发表时间：
2014-04
影响因子：
9.7
通讯作者：
Barker, Thomas H.
中科院分区：
文献类型：
--
作者：
Bryksin, Anton V.;Brown, Ashley C.;Baksh, Michael M.;Finn, M. G.;Barker, Thomas H.
今天建造的许多生物材料都是复杂的化学结构，其中包含了来自自然的生物活性成分，但该领域仍然可以说还处于初级阶段。对能够为医疗和非医疗应用带来复杂的结构、动力学和功能特性的材料的需求只会越来越大。对生物系统功能的日益重视促使生物材料研究人员从自然中获得设计灵感，使用生物分子基元的例子很多。然而，进化作为自然界创造新设计的唯一引擎，在很大程度上被生物材料界忽视了。分子进化是一种新兴的工具，它使人们能够通过变异和选择将自然的工程原理应用于非自然的情况。这篇综述的目的是强调分子进化在合成生物学应用于生物材料工程方面的最新进展，并讨论这种方法在未来可能成功应用的一些领域。
Many biomaterials constructed today are complex chemical structures that incorporate biologically active components derived from nature, but the field can still be said to be in its infancy. The need for materials that bring sophisticated properties of structure, dynamics, and function to medical and non-medical applications will only grow. Increasing appreciation of the functionality of biological systems has caused biomaterials researchers to consider nature for design inspiration, and many examples exist of the use of biomolecular motifs. Yet, evolution, nature's only engine for the creation of new designs, has been largely ignored by the biomaterials community. Molecular evolution is an emerging tool that enables one to apply nature's engineering principles to non-natural situations using variation and selection. The purpose of this review is to highlight the most recent advances in the use of molecular evolution in synthetic biology applications for biomaterial engineering, and to discuss some of the areas in which this approach may be successfully applied in the future.
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