An olfactory virtual reality system for mice.
An olfactory virtual reality system for mice.
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DOI：
10.1038/s41467-018-03262-4
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发表时间：
2018-02-26
影响因子：
16.6
通讯作者：
Dombeck DA
中科院分区：
文献类型：
--
作者：
Radvansky BA;Dombeck DA
All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behavioral experiments. To overcome these challenges, we introduce a system to control and maintain an olfactory virtual landscape. This system uses rapid flow controllers and an online predictive algorithm to deliver precise odorant distributions to head-fixed mice as they explore a virtual environment. We establish an odor-guided virtual navigation behavior that engages hippocampal CA1 “place cells” that exhibit similar properties to those previously reported for real and visual virtual environments, demonstrating that navigation based on different sensory modalities recruits a similar cognitive map. This method opens new possibilities for studying the neural mechanisms of olfactory-driven behaviors, multisensory integration, innate valence, and low-dimensional sensory-spatial processing. Odor-guided spatial behaviours are difficult to study due to the challenge of controlling chemical concentrations in space and time. Here the authors present a precise odor delivery system to generate a olfactory virtual landscape that engages hippocampal place cells in mice.
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影响因子：
16.2
作者：
Aronov, Dmitriy;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
48
作者：
Gershow, Marc;Berck, Matthew;Mathew, Dennis;Luo, Linjiao;Kane, Elizabeth A.;Carlson, John R.;Samuel, Aravinthan D. T.
通讯作者：
Samuel, Aravinthan D. T.
影响因子：
3.4
作者：
Bhattacharyya U;Bhalla US
通讯作者：
Bhalla US
影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
64.5
作者：
Acharya, Lavanya;Aghajan, Zahra M.;Mehta, Mayank R.
通讯作者：
Mehta, Mayank R.