Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches.
Unraveling Psychiatric Disorders through Neural Single-Cell Transcriptomics Approaches.
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单细胞和单核转录组技术的发展使精神疾病的分子和细胞异质性得以解开。大脑的复杂性和不同大脑区域之间的关系可以通过基于其分子标记和转录组学特征对单个细胞群进行分类来更好地理解。对这些独特细胞类型的分析可以解释它们与精神疾病病理学的关系。最近在人类和动物模型中的研究强调了神经元细胞的转录组分析在精神疾病中的重要性，但也揭示了非神经元细胞如少突胶质细胞和小胶质细胞的关键作用。在这篇综述中，我们更新了目前的大脑转录组的研究结果，并探讨了在抑郁症和压力，神经退行性疾病（帕金森病和阿尔茨海默病），精神分裂症，阿片类药物使用障碍，酒精和精神兴奋剂滥用的人类和动物模型中发现的转录组改变的分子研究。我们还评论了单细胞和单核研究的潜在未来方向。
The development of single-cell and single-nucleus transcriptome technologies is enabling the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The complexity of the brain and the relationships between different brain regions can be better understood through the classification of individual cell populations based on their molecular markers and transcriptomic features. Analysis of these unique cell types can explain their involvement in the pathology of psychiatric disorders. Recent studies in both human and animal models have emphasized the importance of transcriptome analysis of neuronal cells in psychiatric disorders but also revealed critical roles for non-neuronal cells, such as oligodendrocytes and microglia. In this review, we update current findings on the brain transcriptome and explore molecular studies addressing transcriptomic alterations identified in human and animal models in depression and stress, neurodegenerative disorders (Parkinson’s and Alzheimer’s disease), schizophrenia, opioid use disorder, and alcohol and psychostimulant abuse. We also comment on potential future directions in single-cell and single-nucleus studies.
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影响因子：
2.8
作者：
Chavoshi, Hossein;Boroujeni, Mahdi Eskandarian;Aliaghaei, Abbas
通讯作者：
Aliaghaei, Abbas
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46.9
作者：
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通讯作者：
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16.6
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