Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete.
Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete.
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DOI：
10.1016/j.epidem.2010.03.005
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发表时间：
2010-06
期刊：
影响因子：
3.8
通讯作者：
Fraser, Christophe
中科院分区：
文献类型：
--
作者：
Hanage, William P.;Finkelstein, Jonathan A.;Huang, Susan S.;Pelton, Stephen I.;Stevenson, Abbie E.;Kleinman, Ken;Hinrichsen, Virginia L.;Fraser, Christophe
关键词：
在2000年针对7种肺炎球菌血清型的结合疫苗接种（PCV 7）后，美国的侵袭性肺炎球菌病（IPD）已经减少。然而，已经观察到由于其他血清型引起的IPD增加，特别是19A。这种“血清型替代”会在多大程度上侵蚀疫苗接种的益处，以及在什么时间尺度上是未知的。我们使用了人口遗传学的方法来测试是否可以检测到疫苗接种的选择性影响，在纵向运输样本，其次多久，它持续了2000年引入疫苗。为了检测疫苗的选择性影响，我们比较了2001年、2004年和2007年收集的马萨诸塞州儿童肺炎球菌携带样本的血清型多样性，以及马萨诸塞州、英国和芬兰在疫苗接种前收集的其他样本。2004年的样本比接种疫苗前的样本更加多样化（p >0.0001），表明疫苗接种的选择压力。2007年的样本与疫苗接种前的样本相比，在多样性方面没有显着差异，并显示出相似的种群结构，但血清型不同。2007年，19A的携带频率与接种疫苗前样本中最常见的血清型相似。我们认为，涉及19 A的血清型替换可能是完全的马萨诸塞州，由于人口结构的相似性，前疫苗样品。这些结果表明，随着疫苗覆盖率的提高，替代现象迅速发生，并可能减轻对未来因19A而导致疾病增加的担忧。对于其他血清型，替代疾病的未来进程仍有待确定。
Invasive pneumococcal disease (IPD) has been reduced in the US following conjugate vaccination (PCV7) targeting seven pneumococcal serotypes in 2000. However, increases in IPD due to other serotypes have been observed, in particular 19A. How much this “serotype replacement” will erode the benefits of vaccination and over what timescale is unknown. We used a population genetic approach to test first whether the selective impact of vaccination could be detected in a longitudinal carriage sample, and secondly how long it persisted for following introduction of vaccine in 2000. To detect the selective impact of the vaccine we compared the serotype diversity of samples from pneumococcal carriage in Massachusetts children collected in 2001, 2004 and 2007 with others collected in the pre-vaccine era in Massachusetts, the UK and Finland. The 2004 sample was significantly (p >0.0001) more diverse than pre-vaccine samples, indicating the selective pressure of vaccination. The 2007 sample showed no significant difference in diversity from the pre-vaccine period, and exhibited similar population structure, but with different serotypes. In 2007 the carriage frequency of 19A was similar to that of the most common serotype in pre-vaccine samples. We suggest that serotype replacement involving 19A may be complete in Massachusetts due to similarities in population structure to pre-vaccine samples. These results suggest that the replacement phenomenon occurs rapidly with high vaccine coverage, and may allay concerns about future increases in disease due to 19A. For other serotypes, the future course of replacement disease remains to be determined.
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影响因子：
3.6
作者：
Pelton, SI;Loughlin, AM;Marchant, CD
通讯作者：
Marchant, CD
DOI：
10.1073/pnas.0406993102
发表时间：
2005-02-08
影响因子：
11.1
作者：
Fraser, C;Hanage, WP;Spratt, BG
通讯作者：
Spratt, BG
影响因子：
11.8
作者：
Byington, CL;Samore, MH;Pavia, AT
通讯作者：
Pavia, AT
影响因子：
158.5
作者：
Eskola, J;Kilpi, T;Ecrola, M
通讯作者：
Ecrola, M
DOI：
10.1099/00221287-144-11-3049
发表时间：
1998-11-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Enright, MC;Spratt, BG
通讯作者：
Spratt, BG