Prognostic role of survivin in bladder cancer: a systematic review and meta-analysis.
Prognostic role of survivin in bladder cancer: a systematic review and meta-analysis.
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Survivin在膀胱癌中的预后作用：系统评价和荟萃分析。
DOI：
10.1371/journal.pone.0076719
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ku JH
中科院分区：
文献类型：
--
作者：
Jeon C;Kim M;Kwak C;Kim HH;Ku JH
本研究的目的是对已发表的研究survivin表达及其对膀胱癌预后影响的文献进行系统回顾和荟萃分析。从1997年8月至2013年5月，我们仔细检索了Pubmed、Cochrane Library和SCOPUS数据库。共有14篇文章符合本系统评价的入选标准。符合条件的研究共纳入2165例患者，每项研究中位患者人数为155例（范围：17-726）。在14项研究中，9项研究评估了福尔马林固定石蜡包埋组织块的免疫组织化学。在非肌肉浸润性膀胱肿瘤中，无复发生存期（合并危险度为1.81,95%可信区间[CI]为1.30-2.52）、无进展生存期（合并危险度为2.12,95% CI为1.60-2.82）、癌症特异性生存期（合并危险度为2.01,95% CI为1.32-3.06）和总生存期（合并危险度为1.53,95% CI为1.02-2.29）的合并危险度比（合并危险度为1.01,95% CI为1.02-2.29）具有统计学意义。在晚期阶段，生存状态的总体hr是稳健的。当仅纳入调整后的生存数据时，所有生存亚组分析均发现具有统计学意义的差异。在大多数荟萃分析中，生存状态的影响在研究间没有异质性。在本荟萃分析中没有明确的发表偏倚证据。Survivin表达表明膀胱癌患者预后较差，但结果应谨慎解释。有必要设计更好的研究和标准化的检测方法，以提供关于survivin表达与膀胱癌患者预后之间关系的更好的结论。
The objective of the present study was to conduct a systematic review and meta-analysis of published literature investigating the survivin expression and its effects on bladder cancer prognosis. We carefully searched online Pubmed, Cochrane Library and SCOPUS database from August 1997 to May 2013. A total of 14 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 2,165 patients with a median number of 155 patients per study (range: 17–726). Of the 14 studies, nine evaluated immunohistochemistry in formalin-fixed paraffin-embedded tissue blocks. In non-muscle invasive bladder tumor, the pooled hazard ratio (HR) was statistically significant for recurrence-free survival (pooled HR, 1.81; 95% confidence interval [CI], 1.30–2.52), progression-free survival (pooled HR, 2.12; 95% CI, 1.60–2.82), cancer-specific survival (pooled HR, 2.01; 95% CI, 1.32–3.06), and overall survival (pooled HR, 1.53; 95% CI, 1.02–2.29). The overall HRs by survivin status were robust across advanced stages. When only adjusted survival data were included, statistically significant differences were identified for all survival subgroup analyses. There was no between-study heterogeneity in the effect of survivin status on the majority of meta-analyses. There was no clear evidence of publication bias in this meta-analysis. Survivin expression indicates worse prognosis in patients with bladder cancer but the results should be interpreted with caution. It is necessary that better-designed studies with standardized assays need to provide a better conclusion about the relationship between survivin expression and the outcome of patients with bladder cancer.
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影响因子：
3.7
作者：
Koga F;Yoshida S;Tatokoro M;Kawakami S;Fujii Y;Kumagai J;Neckers L;Kihara K
通讯作者：
Kihara K
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
50.5
作者：
Gazzaniga, P;Gradilone, A;Aglianò, AM
通讯作者：
Aglianò, AM
影响因子：
51.1
作者：
Karam, Jose A.;Lotan, Yair;Shariat, Shahrokh F.
通讯作者：
Shariat, Shahrokh F.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N