Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.
Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.
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DOI：
10.1038/s41467-021-23267-w
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发表时间：
2021-06-11
影响因子：
16.6
通讯作者：
Jambo KC
中科院分区：
文献类型：
--
作者：
Morton B;Barnes KG;Anscombe C;Jere K;Matambo P;Mandolo J;Kamng'ona R;Brown C;Nyirenda J;Phiri T;Banda NP;Van Der Veer C;Mndolo KS;Mponda K;Rylance J;Phiri C;Mallewa J;Nyirenda M;Katha G;Kambiya P;Jafali J;Mwandumba HC;Gordon SB;Blantyre COVID-19 Consortium;Cornick J;Jambo KC
尽管COVID-19大流行没有一个国家不受影响，但了解非洲人群临床和免疫反应的研究有限。在这里，我们收集了疑似（PCR阴性/IgG阳性）或确诊（PCR阳性）COVID-19住院患者和健康社区对照（PCR阴性/IgG阴性）。PCR阳性COVID-19参与者比PCR阴性/IgG阳性和PCR阴性/IgG阴性参与者更有可能接受地塞米松和β-内酰胺类抗生素治疗，并存活至出院。PCR阴性/IgG阳性参与者表现出与PCR阳性COVID-19参与者类似的鼻和全身细胞因子特征，主要由趋化因子和中性粒细胞主导，与PCR阴性/IgG阴性参与者不同。PCR阴性/IgG阳性受试者的金黄色葡萄球菌和肺炎链球菌定植倾向增加。具有高度COVID-19临床怀疑的PCR阴性/IgG阳性个体具有与PCR证实的疾病类似的炎症特征，并且可能代表COVID-19治疗策略的目标人群。资源匮乏环境中的COVID-19临床管理面临着明显的挑战，需要详细的患者特征描述。在这里，作者描述了马拉维一家医院确诊和疑似COVID-19患者的临床和免疫学特征。
Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies. Clinical management of COVID-19 in resource-poor settings has distinct challenges and detailed patient characterisation is needed. Here, the authors describe the clinical and immunological profiles of patients at a hospital in Malawi with confirmed and suspected COVID-19.
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影响因子：
64.5
作者：
Hou, Yixuan J.;Okuda, Kenichi;Baric, Ralph S.
通讯作者：
Baric, Ralph S.
DOI：
10.1093/cid/ciaa1605
发表时间：
2021-10-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Geretti AM;Stockdale AJ;Kelly SH;Cevik M;Collins S;Waters L;Villa G;Docherty A;Harrison EM;Turtle L;Openshaw PJM;Baillie JK;Sabin CA;Semple MG
通讯作者：
Semple MG
影响因子：
7.7
作者：
Zamorano Cuervo N;Grandvaux N
通讯作者：
Grandvaux N
DOI：
10.1016/j.cmi.2020.07.041
发表时间：
2021-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Garcia-Vidal C;Sanjuan G;Moreno-García E;Puerta-Alcalde P;Garcia-Pouton N;Chumbita M;Fernandez-Pittol M;Pitart C;Inciarte A;Bodro M;Morata L;Ambrosioni J;Grafia I;Meira F;Macaya I;Cardozo C;Casals C;Tellez A;Castro P;Marco F;García F;Mensa J;Martínez JA;Soriano A;COVID-19 Researchers Group
通讯作者：
COVID-19 Researchers Group
影响因子：
11.8
作者：
Amin-Chowdhury, Zahin;Aiano, Felicity;Ladhani, Shamez N.
通讯作者：
Ladhani, Shamez N.