Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
复制标题
自由基清除剂依达拉奉对急性胰腺炎相关肺损伤的保护作用。
DOI：
10.1016/j.ejphar.2009.12.025
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
朱晓燕
中科院分区：
文献类型：
--
作者：
朱晓燕
肺功能受损是大多数重症急性胰腺炎相关死亡的主要原因。氧化应激在胰腺炎及其并发症的发病机制中起着重要作用。因此，在本研究中，我们研究了自由基清除剂依达拉奉的治疗性治疗是否可以保护大鼠免受急性胰腺炎和相关的肺损伤。胰胆管内注入3%牛磺胆酸钠溶液1 ml/kg诱发急性胰腺炎。在诱导胰腺炎后1h和13 h给予依达拉奉（8 mg/kg），24 h后评价胰腺和肺损伤的严重程度。依达拉奉治疗显著降低急性胰腺炎后大鼠肺中升高的丙二醛水平，表明自由基在急性胰腺炎相关肺损伤中的重要作用。此外，依达拉奉对胰腺和肺的中性粒细胞浸润和组织损伤具有显著的保护作用，如血清淀粉酶水平、髓过氧化物酶活性和组织病理学分析所示。依达拉奉治疗还减弱了急性胰腺炎后大鼠肺中促炎细胞因子白细胞介素（IL）-6和肿瘤坏死因子α（TNF-α）mRNA水平的升高。总之，依达拉奉可能通过其抗氧化和抗炎作用保护大鼠免受急性胰腺炎相关肺损伤。因此，依达拉奉有望作为急性胰腺炎患者肺损伤的治疗药物。
Impaired lung function is the primary contributor to most deaths associated with severe acute pancreatitis. It is widely accepted that oxidative stress plays a central role in the pathogenesis of pancreatitis and associated complications. Therefore, in the present study, we investigated whether therapeutic treatment with the free radical scavenger edaravone could protect rats against acute pancreatitis and the associated lung injury. Acute pancreatitis was induced by infusion of 1ml/kg of sodium taurocholate (3% solution) into the biliopancreatic duct. Edaravone (8mg/kg) was administered 1h and 13h after inducing pancreatitis, the severity of pancreatic and pulmonary injuries was evaluated 24h after inducing pancreatitis. Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury. In addition, edaravone showed significant protective effects against neutrophil infiltration and tissue injury in both pancreas and lung, as demonstrated by serum amylase levels, myeloperoxidase activity and histopathological analysis. Edaravone treatment also attenuated the elevated mRNA levels of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) in rat lungs after acute pancreatitis. In conclusion, edaravone protects rats against acute pancreatitis-associated lung injury, probably through its antioxidant and anti-inflammatory effects. Thus, edaravone shows promise as a treatment for lung injury in patients with acute pancreatitis.
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影响因子：
24.3
作者：
S. Tajima;M. Bando;Yoshiki Ishii;T. Hosono;H. Yamasawa;S. Ohno;T. Takada;E. Suzuki;Fumitake Gejyo;Yukihiko Sugiyama
通讯作者：
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影响因子：
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作者：
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DOI：
10.1007/978-3-540-68251-6_1
发表时间：
2009
期刊：
--
影响因子：
--
作者：
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通讯作者：
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