Alveolar pressure-airflow characteristics in humans breathing air, He-O2, and SF6-O2.

Alveolar pressure-airflow characteristics in humans breathing air, He-O2, and SF6-O2.
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人类呼吸空气、He-O2 和 SF6-O2 时的肺泡压力-气流特征。

DOI:
10.1152/jappl.1981.51.4.1033
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发表时间:
1981
期刊:
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子:
--
通讯作者:
IngramJr,RH
IngramJr,RH
中科院分区:
--
文献类型:
--
作者:
Slutsky,AS;Drazen,JM;O'Cain,CF;IngramJr,RH

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在定常流动条件下的刚性管系中,摩擦系数[Cf=2 Delta P/(Rho V2/A2)](其中Delta P是压降,Rho是密度,V是流量,A是横截面面积)应该是雷诺数(Re)的唯一函数。最近已经表明,在任何给定的Re,当呼吸He-O2时,使用跨肺压(PL)的Cf值比呼吸空气时更低(Lisboa等人,J.Appl。呼吸。环境。锻炼身体。48:878-885,1980)。这种不连续性的一种解释是,PL包括组织粘性引起的压降,它与V无关,因此在任何Re下,与He-O2相比,会导致空气中Cf的高估。我们通过在呼吸空气、He-O2和SF6-O2的正常受试者中测量与肺泡压力有关的V而不是PL来检验这一假设。在每个受试者中,对于给定的Re,CF是最大的呼吸SF6-O2,最低的呼吸是He-O2,与使用PL的结果相似。因此,组织粘性并不是Cf与Re曲线不连续的唯一原因,这种现象一定是由于其他因素造成的,例如改变几何形状或不稳定的行为。
In a system of rigid tubes under steady flow conditions, the coefficient of friction [CF = 2 delta P/(rho V2/A2)] (where delta P is pressure drop, rho is density, V is flow, and A is cross-sectional area) should be a unique function of Reynolds' number (Re). Recently it has been shown that at any given Re, the value of CF using transpulmonary pressure (PL) was lower when breathing He-O2 compared with air (Lisboa et al., J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48: 878–885, 1980). One explanation for this discontinuity is that PL includes the pressure drop due to tissue viscance, which is independent of V, and thus would lead to an overestimate of CF on air compared with He-O2 at any Re. We tested this hypothesis by measuring V related to alveolar pressure, rather than PL, in normal subjects breathing air, He-O2, and SF6-O2. In each subject, for a given Re, CF was greatest breathing SF6-O2 and lowest breathing He-O2, similar to results using PL. Thus tissue viscance is not the sole cause of the discontinuous plot of CF vs. Re, and this phenomenon must be due to other factors, such as changing geometry or nonsteady behavior.
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