The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease.
The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺疾病海马的独特改变和认知障碍
DOI：
10.1186/1465-9921-14-140
复制
发表时间：
2013-12-21
影响因子：
5.8
通讯作者：
Fei GH
中科院分区：
文献类型：
--
作者：
Li J;Fei GH
研究背景慢性阻塞性肺疾病（COPD）患者存在认知功能障碍。然而，大脑的结构改变和潜在的机制知之甚少。MethodsThirteen轻度至中度COPD患者，48例重度COPD患者，和31名对照组被招募的认知测试和神经影像学研究。S100 B，肺功能和动脉血气水平的血清水平也进行了评价，在每个subject.ResultsThe海马体积显着小于COPD患者相比，对照组。轻中度COPD患者的SaO2与MMSE评分呈正相关，轻中度COPD患者的PaO2与重度COPD患者的PaO2呈正相关。与对照受试者相比，在轻中度COPD患者中观察到较高的S100 B浓度，而在重度COPD患者中发现最高的S100 B水平。S100 B水平与MMSE在轻中度和重度COPD患者中呈负相关，也与海马体积在总COPD patient.ConclusionsHippocampus萎缩的基础上，通过磁共振成像定量评估COPD患者，这可能与认知功能障碍和最普遍的机制负责慢性低氧血症COPD海马萎缩。血清S100B水平升高可能是COPD患者认知功能损害的外周血生化指标。
BackgroundCognitive impairment has been found in chronic obstructive pulmonary disease (COPD) patients. However, the structural alteration of the brain and underlying mechanisms are poorly understood.MethodsThirty-seven mild-to-moderate COPD patients, forty-eight severe COPD patients, and thirty-one control subjects were recruited for cognitive test and neuroimaging studies. Serum levels of S100B,pulmonary function and arterial blood gas levels were also evaluated in each subject.ResultsThe hippocampal volume was significantly smaller in COPD patients compared to the control group. It is positively correlated with a mini mental state examination (MMSE) score, SaO2in mild-to-moderate COPD patients, the levels of PaO2in both mild-to-moderate and severe COPD patients. Higher S100B concentrations were observed in mild-to-moderate COPD patients, while the highest S100B level was found in severe COPD patients when compared to the control subjects. S100B levels are negatively associated with MMSE in both mild-to-moderate and severe COPD patients and also negatively associated with the hippocampal volume in the total COPD patients.ConclusionsHippocampal atrophy based on quantitative assessment by magnetic resonance imaging does occur in COPD patients, which may be associated with cognitive dysfunction and the most prevalent mechanism accountable for hippocampal atrophy is chronic hypoxemia in COPD. Higher serum S100B levels may be peripheral biochemical marker for cognitive impairment in COPD.
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影响因子：
4.8
作者：
Braga, Carla W.;Martinez, Denis;Souza, Diogo Onofre
通讯作者：
Souza, Diogo Onofre
DOI：
10.1164/rccm.200902-0276oc
发表时间：
2009-07-15
影响因子：
24.7
作者：
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作者：
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作者：
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通讯作者：
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慢性阻塞性肺疾病患者认知障碍及相关因素的评价
影响因子：
3.7
作者：
Li, Jing;Huang, Yun;Fei, Guang-He
通讯作者：
Fei, Guang-He