Lateral habenular norepinephrine contributes to states of arousal and anxiety in male rats.
Lateral habenular norepinephrine contributes to states of arousal and anxiety in male rats.
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DOI：
10.1016/j.bbr.2018.03.012
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发表时间：
2018-07-16
影响因子：
2.7
通讯作者：
Ettenberg A
中科院分区：
文献类型：
--
作者：
Purvis EM;Klein AK;Ettenberg A
最近的研究发现外侧缰核 (LHb) 是一个在应激和焦虑状态产生中发挥重要作用的大脑区域。此外，长期以来人们都知道去甲肾上腺素 (NE) 与兴奋、压力和焦虑有关，并且已确定 NE 对 LHb 的投射来自蓝斑 (LC)。目前的研究旨在检验 LHb 内 NE 释放导致焦虑行为发生的假设。雄性大鼠被植入针对 LHb 的双侧引导插管，随后接受选择性 α2 肾上腺素能自身受体激动剂右美托咪定 (DEX)（0、0.5、1.0 μg/侧）颅内（IC）输注治疗，然后在自发运动、旷场行为和运动测试中评估动态和焦虑行为。 声学惊吓反应。结果表明，两种剂量的 DEX 给药均显着降低了受试者的整体运动行为，表明即使将小剂量的 α2 激动剂输注到 LHb 中也可以对受试者的总体警觉性和活动水平产生深远的影响。 DEX 还被发现可以减轻焦虑，这一点可以通过减少对 110 分贝声音刺激的惊吓反应幅度来证明。总而言之，这些结果确定了 LHb 内 NE 释放在唤醒和焦虑中的作用。
Recent research has identified the lateral habenula (LHb) as a brain region playing an important role in the production of stressful and anxiogenic states. Additionally, norepinephrine (NE) has long been known to be involved in arousal, stress and anxiety, and NE projections to the LHb have been identified emanating from the locus coeruleus (LC). The current research was devised to test the hypothesis that NE release within the LHb contributes to the occurrence of anxiogenic behaviors. Male rats were implanted with bilateral guide cannula aimed at the LHb and subsequently treated with intracranial (IC) infusions of the selective α2 adrenergic autoreceptor agonist, dexmedetomidine (DEX) (0, 0.5, 1.0 μg/side), prior to assessment of ambulatory and anxiogenic behavior in tests of spontaneous locomotion, open field behavior, and acoustic startle-response. Results demonstrated that DEX administration significantly reduced the overall locomotor behavior of subjects at both doses indicating that infusion of even small doses of this α2 agonist into the LHb can have profound effects on the subjects’ general levels of alertness and activity. DEX was also found to attenuate anxiety as evidenced by a reduction in the magnitude of a startle-response to an acoustic 110 dB stimulus. Taken together, these results identify a role for NE release within the LHb in both arousal and anxiety.
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影响因子：
3.6
作者：
FENDT, M;KOCH, M;SCHNITZLER, HU
通讯作者：
SCHNITZLER, HU
缰核：脊椎动物大脑中保守的不对称中继站。
DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
Bianco, Isaac H.;Wilson, Stephen W.
通讯作者：
Wilson, Stephen W.
影响因子：
2.9
作者：
GOTTESFELD, Z
通讯作者：
GOTTESFELD, Z
影响因子：
25
作者：
Bromberg-Martin ES;Hikosaka O
通讯作者：
Hikosaka O
影响因子：
5.6
作者：
Garrity, Abigail G.;Botta, Simhadri;Lydic, Ralph
通讯作者：
Lydic, Ralph