Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study
Sugar-containing beverage intake at the age of 1 year and cardiometabolic health at the age of 6 years: the Generation R Study
复制标题
1 岁时的含糖饮料摄入量和 6 岁时的心脏代谢健康状况：R 世代研究
DOI：
--
复制
发表时间：
2015
影响因子：
8.7
通讯作者：
Jessica C. Kiefte
中科院分区：
文献类型：
--
作者：
E. T. Leermakers;J. Felix;V. Jaddoe;H. Raat;O. Franco;Jessica C. Kiefte
研究背景成年人饮用含糖饮料（SCB）与代谢综合征风险增加有关。虽然SCB对儿童体重的影响已得到充分证实，但对幼儿的心脏代谢影响知之甚少。我们研究了协会的SCB摄入量在1岁时与心脏代谢健康在6 years.MethodsThis研究进行了2,045荷兰儿童从人口为基础的前瞻性出生队列。在13个月龄时，用半定量食物频率问卷评估SCB摄入量，并创建性别特异性三分位数。孩子们在6岁时参观了研究中心。我们创建了一个连续的心脏代谢危险因素评分，包括：体脂百分比，血压，胰岛素，HDL-胆固醇和甘油三酯。为所有结局创建了性别特异性标准差（SD）评分。多变量线性回归进行调整的社会人口和生活方式变量的母亲和child.ResultsIn总人口，我们观察到之间的关联较高的SCB摄入量在13个月的年龄和较高的心脏代谢危险因素评分在6岁（0.13SD（95% CI 0.01; 0.25），最高与最低三分位数）按性别分层后，我们发现SCB摄入量最高三分位数的男孩具有较高的心脏代谢危险因素评分，（0.18 SD（95% CI 0.01; 0.34）），与SCB摄入量最低三分位数的男孩相比。在女孩中没有明显的关联。我们没有发现协会的SCB摄入量与个人的心脏代谢危险因素的总人口，或在分层analysis.ConclusionHigher SCB摄入量在1岁时与较高的心脏代谢危险因素评分在6岁的男孩，但不是在女孩。需要进一步研究SCBs的性别特异性效应。
BackgroundConsumption of sugar-containing beverages (SCBs) in adults has been associated with an increased risk of metabolic syndrome. Although the effect of SCB on body weight in children is well established, little is known about the cardiometabolic effects in young children. We studied the associations of SCB intake at the age of 1 year with cardiometabolic health at age 6 years.MethodsThis study was performed among 2,045 Dutch children from a population based prospective birth cohort. SCB intake was assessed with a semi-quantitative food frequency questionnaire at the age of 13 months and sex-specific tertiles were created. Children visited the research center at the age of 6 years. We created a continuous cardiometabolic risk factor score including: body fat percentage, blood pressure, insulin, HDL-cholesterol and triglycerides. Age-and sex-specific standard deviation (SD) scores were created for all outcomes. Multivariable linear regression was performed with adjustment for socio-demographic and lifestyle variables of mother and child.ResultsIn the total population, we observed an association between higher SCB intake at 13 months of age and a higher cardiometabolic risk factor score at the age of 6 years (0.13SD (95 % CI 0.01; 0.25), highest vs. lowest tertile) After stratification by sex, we found that boys in the highest tertile of SCB intake had a higher cardiometabolic risk factor score (0.18 SD (95 % CI 0.01; 0.34)), as compared to boys in the lowest tertile of SCB intake. There was no significant association in girls. We did not find associations of SCB intake with the individual cardiometabolic risk factors in the total population, or in the stratified analyses.ConclusionHigher SCB intake at 1 year of age was associated with a higher cardiometabolic risk factor score at age 6 years in boys, but not in girls. Further research on sex-specific effects of SCBs is needed.
登录
查看更多内容
DOI：
--
发表时间：
2013
期刊：
--
影响因子：
--
作者：
F. B. Hu
通讯作者：
F. B. Hu
影响因子：
5
作者：
MICKEY, RM;GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
15.9
作者：
Stanhope, Kimber L.;Schwarz, Jean Marc;Havel, Peter J.
通讯作者：
Havel, Peter J.
影响因子：
7.1
作者：
Willett, WC;Howe, GR;Kushi, LH
通讯作者：
Kushi, LH
影响因子：
7.1
作者：
Kell, Kenneth P.;Cardel, Michelle I.;Ferndandez, Jose R.
通讯作者：
Ferndandez, Jose R.