Reproducibility of 7-T brain spectroscopy using an ultrashort echo time STimulated Echo Acquisition Mode sequence and automated voxel repositioning.
Reproducibility of 7-T brain spectroscopy using an ultrashort echo time STimulated Echo Acquisition Mode sequence and automated voxel repositioning.
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DOI：
10.1002/nbm.4631
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发表时间：
2022-03
影响因子：
2.9
通讯作者：
Salibi N
中科院分区：
文献类型：
--
作者：
Reid MA;Forloines MR;Salibi N
建立脑MRS的可重复性对临床研究很重要，这样研究人员就可以评估由于治疗或疾病过程而引起的代谢物变化，并更好地了解健康和紊乱状态下的大脑。先前使用刺激回波采集模式（STEAM）序列进行的7-T MRS重复性研究主要集中在前扣带皮层或后扣带皮层和楔前叶。本研究的目的是利用超短回波时间（TE） STEAM序列和自动体素重新定位来评估背外侧前额叶皮层（DLPFC）代谢物测量的可重复性。使用AutoAlign方法对9名受试者进行体素重新定位，在两次扫描过程中获得光谱。用变异系数（cv）和百分比差异评价重现性。主要代谢物谷氨酸、n -乙酰天冬氨酸、总肌酸、总胆碱和肌醇的平均受试者内cv小于6%。对于GABA、谷氨酰胺、谷胱甘肽和牛磺酸的较小信号，平均cv小于20%。这些结果表明，使用具有超短TE和自动体素重定位的STEAM序列的7-T MRS在DLPFC中提供了极好的代谢物再现性。
Establishing the reproducibility of brain MRS is important for clinical studies so that researchers can evaluate changes in metabolites due to treatment or the course of a disease and better understand the brain in healthy and disordered states. Prior 7-T MRS reproducibility studies using the stimulated echo acquisition mode (STEAM) sequence have focused on the anterior cingulate cortex or posterior cingulate cortex and precuneus. The purpose of this study was to evaluate the reproducibility of metabolite measurements in the dorsolateral prefrontal cortex (DLPFC) using an ultrashort echo time (TE) STEAM sequence and automated voxel repositioning. Spectra were acquired during two scan sessions from nine subjects using the AutoAlign method for voxel repositioning. Reproducibility was evaluated with coefficients of variation (CVs) and percentage differences. The mean intrasubject CVs were less than 6% for the major metabolites glutamate, N-acetylaspartate, total creatine, total choline, and myo-inositol. The mean CVs were less than 20% for the smaller signals of GABA, glutamine, glutathione, and taurine. These results indicate that 7-T MRS using a STEAM sequence with ultrashort TE and automated voxel repositioning provides excellent reproducibility of metabolites in the DLPFC.
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影响因子：
2.9
作者：
通讯作者：
--
MRS的运动校正方法：专家的共识建议。
影响因子：
2.9
作者：
Andronesi OC;Bhattacharyya PK;Bogner W;Choi IY;Hess AT;Lee P;Meintjes EM;Tisdall MD;Zaitzev M;van der Kouwe A
通讯作者：
van der Kouwe A
影响因子：
4.7
作者：
Marsman A;Boer VO;Luijten PR;Hulshoff Pol HE;Klomp DWJ;Mandl RCW
通讯作者：
Mandl RCW
影响因子：
5.3
作者：
Dou, Weiqiang;Palomero-Gallagher, Nicola;Walter, Martin
通讯作者：
Walter, Martin
影响因子：
3.3
作者：
Hofmann, L;Slotboom, J;Kreis, R
通讯作者：
Kreis, R