Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.
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DOI：
10.1186/1471-2466-14-164
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发表时间：
2014-10-24
影响因子：
3.1
通讯作者：
COPDGene and ECLIPSE Investigators
中科院分区：
文献类型：
--
作者：
Hersh CP;Make BJ;Lynch DA;Barr RG;Bowler RP;Calverley PM;Castaldi PJ;Cho MH;Coxson HO;DeMeo DL;Foreman MG;Han MK;Harshfield BJ;Hokanson JE;Lutz S;Ramsdell JW;Regan EA;Rennard SI;Schroeder JD;Sciurba FC;Steiner RM;Tal-Singer R;van Beek E Jr;Silverman EK;Crapo JD;COPDGene and ECLIPSE Investigators
慢性阻塞性肺疾病（COPD）通常分为蓝色肿胀和粉红色肿胀。这些临床亚型的效用尚不清楚。然而，气道主导型和肺气肿主导型COPD之间的更广泛区别可能具有临床意义。目的是确定肺气肿为主和非肺气肿COPD患者的临床特征。来自COPD遗传流行病学研究（COPDGene）的当前和既往吸烟者进行了胸部计算机断层扫描（CT）和定量图像分析。以肺气肿为主的COPD定义为-950 Hounsfield单位（LAA-950）≥ 10%的低衰减面积。非肺气肿性COPD定义为气流阻塞伴最小至无肺气肿（LAA-950 < 5%）。在4197例COPD受试者中，1687例被分类为肺气肿为主，1817例被分类为非肺气肿; 693例LAA-950在5-10%之间，未分类。以肺气肿为主的COPD受试者年龄较大（65.6 vs 60.6岁，p < 0.0001）根据气流阻塞，COPD更严重（FEV 1 44.5 vs 68.4%，p < 0.0001），运动限制更大（6分钟步行距离1138 vs 1331 ft，p < 0.0001）和生活质量降低（圣乔治呼吸问卷评分43 vs 31，p < 0.0001）。自我报告的糖尿病在非肺气肿性COPD中更常见（OR 2.13，p < 0.001），这也是使用基于药物使用的糖尿病严格定义证实的。在ECLIPSE研究中重复了糖尿病与非肺气肿性COPD之间的相关性。非肺气肿性COPD（定义为胸部CT扫描显示气流阻塞伴少量肺气肿）与糖尿病风险增加相关。没有肺气肿的COPD患者可能需要更密切地监测糖尿病、高血压和高脂血症，反之亦然。Clinicaltrials.gov标识符：COPDGene NCT 00608764、ECLIPSE NCT 00292552。本文的在线版本（doi：10.1186/1471-2466-14-164）包含补充材料，可供授权用户使用。
Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway-predominant and emphysema-predominant COPD may be clinically relevant. The objective was to define clinical features of emphysema-predominant and non-emphysematous COPD patients. Current and former smokers from the Genetic Epidemiology of COPD Study (COPDGene) had chest computed tomography (CT) scans with quantitative image analysis. Emphysema-predominant COPD was defined by low attenuation area at -950 Hounsfield Units (LAA-950) ≥10%. Non-emphysematous COPD was defined by airflow obstruction with minimal to no emphysema (LAA-950 < 5%). Out of 4197 COPD subjects, 1687 were classified as emphysema-predominant and 1817 as non-emphysematous; 693 had LAA-950 between 5–10% and were not categorized. Subjects with emphysema-predominant COPD were older (65.6 vs 60.6 years, p < 0.0001) with more severe COPD based on airflow obstruction (FEV1 44.5 vs 68.4%, p < 0.0001), greater exercise limitation (6-minute walk distance 1138 vs 1331 ft, p < 0.0001) and reduced quality of life (St. George’s Respiratory Questionnaire score 43 vs 31, p < 0.0001). Self-reported diabetes was more frequent in non-emphysematous COPD (OR 2.13, p < 0.001), which was also confirmed using a strict definition of diabetes based on medication use. The association between diabetes and non-emphysematous COPD was replicated in the ECLIPSE study. Non-emphysematous COPD, defined by airflow obstruction with a paucity of emphysema on chest CT scan, is associated with an increased risk of diabetes. COPD patients without emphysema may warrant closer monitoring for diabetes, hypertension, and hyperlipidemia and vice versa. Clinicaltrials.gov identifiers: COPDGene NCT00608764, ECLIPSE NCT00292552. The online version of this article (doi:10.1186/1471-2466-14-164) contains supplementary material, which is available to authorized users.
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影响因子：
5.8
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
影响因子：
24.3
作者：
Boschetto, P;Miniati, M;Mapp, CE
通讯作者：
Mapp, CE
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
5
作者：
Beckett, M;Weinstein, M;Lin, YH
通讯作者：
Lin, YH
影响因子：
158.5
作者：
Celli, BR;Cote, CG;Cabral, HJ
通讯作者：
Cabral, HJ