Characterisation of COPD heterogeneity in the ECLIPSE cohort.
Characterisation of COPD heterogeneity in the ECLIPSE cohort.
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DOI：
10.1186/1465-9921-11-122
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发表时间：
2010-09-10
影响因子：
5.8
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
中科院分区：
文献类型：
--
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
慢性阻塞性肺疾病（COPD）是一种具有肺部和肺外表现的复杂疾病。本研究描述了一个大型、特征良好且控制良好的COPD队列（ECLIPSE）中COPD的异质性。我们研究了2164例临床稳定的COPD患者，337例肺功能正常的吸烟者和245例从不吸烟者。在这些人中，我们测量了临床参数，营养状况，肺功能测定，运动耐量，并通过计算机断层扫描肺气肿的数量。COPD患者的年龄比对照组稍大，并且比肺功能正常的吸烟者有更多的吸烟包年。COPD患者的合并症比对照组更普遍，无论GOLD分期如何，合并症的发生程度相同。COPD患者气流受限的严重程度与研究前一年报告的呼吸困难程度、健康状况、合并症的存在、运动能力和急性加重次数相关性较差。这些变量在每个GOLD阶段内的分布很广。即使在严重气流阻塞的受试者中，也有相当比例的受试者没有报告症状、加重或运动受限。肺气肿的数量随着GOLD严重程度的增加而增加。支气管扩张的患病率较低（4%），但也随着GOLD分期的增加而增加。还发现了一些性别差异。COPD的临床表现是高度可变的，气流受限的程度不能反映疾病的异质性。
Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
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影响因子：
10
作者：
He JQ;Foreman MG;Shumansky K;Zhang X;Akhabir L;Sin DD;Man SF;DeMeo DL;Litonjua AA;Silverman EK;Connett JE;Anthonisen NR;Wise RA;Paré PD;Sandford AJ
通讯作者：
Sandford AJ
影响因子：
105.7
作者：
FLETCHER, C;PETO, R
通讯作者：
PETO, R
影响因子：
9.6
作者：
de Torres, JP;Casanova, C;Celli, BR
通讯作者：
Celli, BR
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
--
影响因子：
9.6
作者：
Burgel, Pierre-Regis;Nesme-Meyer, Pascale;Roche, Nicolas
通讯作者：
Roche, Nicolas