Diagnostic accuracy of ascitic cholesterol concentration for malignant ascites: a meta-analysis.
Diagnostic accuracy of ascitic cholesterol concentration for malignant ascites: a meta-analysis.
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腹水胆固醇浓度对恶性腹水的诊断准确性：荟萃分析。
DOI：
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发表时间：
2015-10
影响因子：
0.1
通讯作者：
Huang, Ying
中科院分区：
文献类型：
--
作者：
Liu, Xia;Zhao, Yaqin;Liu, Taiguo;Huang, Ying
许多研究已经调查了腹水胆固醇是否可以帮助诊断恶性相关性腹水（MRA），结果有很大差异。为了获得一个更可靠的答案，这个问题，我们荟萃分析了文献使用腹水胆固醇作为诊断测试，以帮助确定磁共振血管造影。系统检索文献数据库，以研究腹水胆固醇诊断MRA的准确性。使用随机效应模型汇总敏感性、特异性、阳性/阴性似然比（PLR/NLR）和诊断比值比（DOR）数据。使用受试者工作特征（SROC）曲线和曲线下面积（AUC）总结总体试验性能。最后，我们的荟萃分析纳入了8个研究，涉及743名受试者。MRA诊断腹水胆固醇的总估计值如下：敏感性，0.82（95% CI 0.78 - 0.86）;特异性，0.90（95% CI 0.87至0.93）; PLR，9.24（95% CI 4.58至18.66）; NLR，0.16（95% CI 0.08至0.32）;和DOR，66.96（95% CI 18.83至238.11）。AUC为0.96。腹水胆固醇水平有助于MRA的诊断。然而，腹水胆固醇测定的结果应与传统试验和临床信息的结果并行解释。
Many studies have investigated whether ascitic cholesterol can aid in diagnosis of malignant related ascites (MRA), and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using ascitic cholesterol as diagnostic tests to help identify MRA. Literature databases were systematically searched for studies examining accuracy of ascitic cholesterol for diagnosing MRA. Data on sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), and diagnostic odds ratio (DOR) were pooled using random effects models. Summary receiver operating characteristic (SROC) curves and area under the curve (AUC) were used to summarize overall test performance. At last, our meta-analysis included 8 studies involving 743 subjects. Summary estimates for ascitic cholesterol in the diagnosis of MRA were as follows: sensitivity, 0.82 (95% CI 0.78 to 0.86); specificity, 0.90 (95% CI 0.87 to 0.93); PLR, 9.24 (95% CI 4.58 to 18.66); NLR, 0.16 (95% CI 0.08 to 0.32); and DOR, 66.96 (95% CI 18.83 to 238.11). The AUC was 0.96. The ascitic cholesterol level is helpful for the diagnosis of MRA. Nevertheless, the results of ascitic cholesterol assays should be interpreted in parallel with the results of traditional tests and clinical information.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
1.9
作者：
P. Brøndum Mortensen;S. Dalby Kristensen;A. Bloch;B. Ascanius Jacobsen;S. Nørby Rasmussen
通讯作者：
P. Brøndum Mortensen;S. Dalby Kristensen;A. Bloch;B. Ascanius Jacobsen;S. Nørby Rasmussen
DOI：
--
发表时间：
2005-03
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
S. Rana;S. V. Babu;R. Kocchar
通讯作者：
S. Rana;S. V. Babu;R. Kocchar
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
Pentti Nieminen;James Carpenter;Gerta Rucker;Martin Schumacher
通讯作者：
Pentti Nieminen;James Carpenter;Gerta Rucker;Martin Schumacher
影响因子：
6.2
作者：
V. Noto;H. Taper;Jiang Yi-hua;J. Janssens;J. Bonté;W. De Loecker
通讯作者：
V. Noto;H. Taper;Jiang Yi-hua;J. Janssens;J. Bonté;W. De Loecker