Lymphocytic infiltrates of the conjunctiva and orbit: immunohistochemical staining of 16 cases.

Lymphocytic infiltrates of the conjunctiva and orbit: immunohistochemical staining of 16 cases.
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结膜和眼眶淋巴细胞浸润:16例免疫组化染色。

DOI:
10.1093/ajcp/81.4.447
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发表时间:
1984
影响因子:
3.5
通讯作者:
R. Warnke
R. Warnke
中科院分区:
医学4区
文献类型:
--
作者:
R. Turner;P. Egbert;R. Warnke

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作者对 16 例眼部淋巴细胞浸润病例进行了冰冻切片免疫染色,并将结果与​​临床和组织学发现相关联。他们的病例包括炎性假瘤 (3)、反应性淋巴组织增生 (3)、非典型淋巴细胞浸润 (9) 和小裂细胞淋巴瘤 (1)。 9 例非典型淋巴细胞浸润病例中有 7 例表达一种免疫球蛋白轻链,而组织学评估中认为反应性的 6 例中只有 1 例的免疫学结果提示肿瘤性 B 细胞增殖。滤泡性小裂细胞淋巴瘤表达B系抗原,但不表达免疫球蛋白;该患者在结膜受累两年后死于播散性淋巴瘤。对 T 淋巴细胞的百分比和亚群比率进行了定量,并在反应性和肿瘤性病变中显示出相似的结果。具有反应性病变的患者和具有单型免疫球蛋白的非典型淋巴细胞浸润的患者之间的临床表现或随访信息没有明显差异。
The authors have performed frozen section immunologic stains on 16 cases of ocular lymphocytic infiltrates and correlated the results with clinical and histologic findings. Their cases included inflammatory pseudotumor (3), reactive lymphoid hyperplasia (3), atypical lymphocytic infiltrate (9), and small cleaved cell lymphoma (1). Seven of the nine cases with an atypical lymphocytic infiltrate expressed one immunoglobulin light chain, while only one of six considered reactive on histologic evaluation had immunologic results suggestive of a neoplastic B cell proliferation. The case of follicular small cleaved cell lymphoma expressed B lineage antigens but did not express immunoglobulin; this patient died of disseminated lymphoma two years after conjunctival involvement. Percentages and subset ratios of T lymphocytes were quantitated and showed similar results in reactive and neoplastic lesions. There is no apparent difference in clinical presentation or follow-up information between patients with reactive lesions and those having an atypical lymphocytic infiltrate with monotypic immunoglobulin.
DOI: 10.1001/archopht.1982.01030030086007
发表时间: 1982
期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子: --
作者:
Jakobiec,FA;Iwamoto,T;Knowles2nd,DM
通讯作者: Knowles2nd,DM
眼附属器淋巴肿瘤表面抗原Leu 1的表达。
DOI: 10.1016/0002-9394(82)90082-4
发表时间: 1982
影响因子: 4.2
作者:
Knowles2nd,DM;Jakobiec,FA;Wang,CY
通讯作者: Wang,CY
通过杂交瘤单克隆抗体鉴定眼附属器肿瘤中的 T 淋巴细胞。
DOI: 10.1016/0002-9394(83)90019-3
发表时间: 1983
影响因子: 4.2
作者:
Knowles2nd,DM;Jakobiec,FA
通讯作者: Jakobiec,FA
DOI: 10.1001/archopht.1981.03930010311020
发表时间: 1981
期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子: --
作者:
Knowles2nd,DM;Jakobiec,FA
通讯作者: Jakobiec,FA