Early development of letter specialization in left fusiform is associated with better word reading and smaller fusiform face area.
Early development of letter specialization in left fusiform is associated with better word reading and smaller fusiform face area.
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DOI：
10.1111/desc.12658
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发表时间：
2018-09
影响因子：
3.7
通讯作者：
Gabrieli J
中科院分区：
文献类型：
--
作者：
Centanni TM;Norton ES;Park A;Beach SD;Halverson K;Ozernov-Palchik O;Gaab N;Gabrieli J
在阅读的过程中，左侧梭状回的一个功能区“视觉词形区”（VWFA）对印刷文字的反应比对其他视觉刺激的反应更强烈。在这里，我们研究了5岁和6岁的早期幼儿园儿童（N=48），很少或根本没有校本阅读指导谁在他们的阅读能力不同的信件的反应。我们使用功能性磁共振成像（fMRI）来测量左、右梭状回对单个字母、假字体和面孔的反应。然后，我们评估了这些区域中的字母敏感皮层（对字母的激活大于对面孔的激活）和字母特异性皮层（对字母的激活大于对假字体的激活）的信号变化和大小（空间范围）是否与（a）单词阅读能力的标准化测量和（B）面部敏感皮层的信号变化和大小（梭形面部区域或FFA;对面孔的激活大于对字母的激活）有关。左侧梭状回的字母特异性更强，但字母敏感性不强，与单词阅读成绩呈正相关。在儿童中，在左侧梭状回，较大的字母敏感皮质与较小的FFA相关。这些研究结果首次表明，在初级读者中，左梭状皮质的字母反应性的发展与更好的阅读能力以及左FFA的大小减少有关，这可能导致右半球对面部感知的优势。
A functional region of left fusiform gyrus termed “the visual word form area” (VWFA) develops during reading acquisition to respond more strongly to printed words than to other visual stimuli. Here, we examined responses to letters among 5- and 6-year-old early Kindergarten children (N=48) with little or no school-based reading instruction who varied in their reading ability. We used functional magnetic resonance imaging (fMRI) to measure responses to individual letters, false fonts, and faces in left and right fusiform gyri. We then evaluated whether signal change and size (spatial extent) of letter-sensitive cortex (greater activation for letters versus faces) and letter-specific cortex (greater activation for letters versus false fonts) in these regions related to (a) standardized measures of word-reading ability and (b) signal change and size of face-sensitive cortex (fusiform face area or FFA; greater activation for faces versus letters). Greater letter specificity, but not letter sensitivity, in left fusiform gyrus correlated positively with word reading scores. Across children, in the left fusiform gyrus, greater size of letter-sensitive cortex correlated with lesser size of FFA. These findings are the first to suggest that in beginning readers, development of letter responsivity in left fusiform cortex is associated with both better reading ability and also a reduction of the size of left FFA that may result in right-hemisphere dominance for face perception.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
2.9
作者：
James, KH;James, TW;Gauthier, I
通讯作者：
Gauthier, I
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
2.5
作者：
Centanni, Tracy M.;King, Livia W.;Gabrieli, John D. E.
通讯作者：
Gabrieli, John D. E.