Neuronal circuitry for pain processing in the dorsal horn.

Neuronal circuitry for pain processing in the dorsal horn.
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DOI:
10.1038/nrn2947
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发表时间:
2010-12
影响因子:
34.7
通讯作者:
Todd, Andrew J.
Todd, Andrew J.
中科院分区:
医学1区
文献类型:
--
作者:
Todd, Andrew J.

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脊髓背角中的神经元处理感觉信息,然后将其传输到几个大脑区域,包括负责疼痛感知的区域。背角为新型镇痛药的开发提供了许多潜在的靶点,并且被认为经历了导致神经损伤和炎症后感觉到的夸大疼痛的变化。尽管它的重要性显而易见,但我们对处理感觉信息的神经元回路仍然知之甚少,主要是因为组成这些回路的各种神经元成分的异质性。最近的研究已经开始阐明这个复杂区域的神经元组织和电路。
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics, and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organisation and circuitry of this complex region.
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