Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area.
Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area.
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DOI：
10.1002/cne.22081
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发表时间：
2009-08-20
期刊：
影响因子：
--
通讯作者：
Todd AJ
中科院分区：
文献类型：
--
作者：
Al-Khater KM;Todd AJ
第一层的投射神经元，以及表达神经激肽1受体（NK 1 r）的第III-IV层的投射神经元，形成了伤害性信息到达大脑的主要途径。这些细胞的轴突支配各种靶点，包括丘脑、中脑导水管周围灰质（PAG）和臂旁外侧区（LPb），并且许多细胞投射到一个以上的靶点。本研究的目的是量化从宫颈增大到PAG和LPb的投射，确定从PAG和LPb标记的腰和颈水平脊髓丘脑神经元的比例，并研究投射群体之间的形态差异。C7节段含有较少的板I spinoparabrachial细胞比L4，但类似数量的spino-PAG细胞。几乎所有的脊髓丘脑I层神经元在这两个水平标记LPb和三分之一和一半之间的PAG。这表明，所有三个目标都有相当多的人。脊髓丘脑I层神经元不同于那些只从LPb标记的，他们一般较大，更经常多极，和（在颈部扩大）有较强的NK 1 R免疫反应。大多数在这两个水平的III/IV层NK 1 r细胞投射到LPb，但很少标记PAG。这些细胞中的绝大多数在C7和超过四分之一的L4脊髓丘脑，并在每个级别的一些投射到丘脑和LPb。这些结果证实，在这些板层的神经元有广泛的侧支投射，并建议在板I不同的神经元亚群有特征性的脊髓上投射模式。神经学比较杂志515：629-646，2009.
Projection neurons in lamina I, together with those in laminae III–IV that express the neurokinin 1 receptor (NK1r), form a major route through which nociceptive information reaches the brain. Axons of these cells innervate various targets, including thalamus, periaqueductal gray matter (PAG), and lateral parabrachial area (LPb), and many cells project to more than one target. The aims of this study were to quantify projections from cervical enlargement to PAG and LPb, to determine the proportion of spinothalamic neurons at lumbar and cervical levels that were labelled from PAG and LPb, and to investigate morphological differences between projection populations. The C7 segment contained fewer lamina I spinoparabrachial cells than L4, but a similar number of spino-PAG cells. Virtually all spinothalamic lamina I neurons at both levels were labelled from LPb and between one-third and one-half from PAG. This suggests that significant numbers project to all three targets. Spinothalamic lamina I neurons differed from those labelled only from LPb in that they were generally larger, were more often multipolar, and (in cervical enlargement) had stronger NK1r immunoreactivity. Most lamina III/IV NK1r cells at both levels projected to LPb, but few were labelled from PAG. The great majority of these cells in C7 and over one-fourth of those in L4 were spinothalamic, and at each level some projected to both thalamus and LPb. These results confirm that neurons in these laminae have extensive collateral projections and suggest that different neuronal subpopulations in lamina I have characteristic patterns of supraspinal projection. J. Comp. Neurol. 515:629–646, 2009.
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